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Journal of Virology, April 2001, p. 3383-3390, Vol. 75, No. 7
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.7.3383-3390.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Viral Regulation of RANTES Expression during Human Cytomegalovirus Infection of Endothelial Cells

Marcella Billstrom Schroeder* and G. Scott Worthen

Program of Cell Biology, Department of Medicine, National Jewish Medical and Research Center, and Department of Medicine, University of Colorado Health Science Center, Denver, Colorado 80206

Received 23 September 2000/Accepted 9 January 2001

Human cytomegalovirus (HCMV) evades healthy immune responses during infection, and this evasion may allow HCMV to establish latency in the host. The human vasculature has been recognized as a site of HCMV infection and may also be a site of latent HCMV infection. As the interface between circulating cells and underlying parenchymal cells, the vascular endothelium provides signals for local reaction of inflammatory cells. We propose that HCMV down-regulates expression of the proinflammatory chemokine RANTES from the infected endothelium, which may result in reduced recruitment of mononuclear cells to the site of infection. Abortive HCMV infection of primary endothelial cells with the clinical isolate HCMV 4010, under conditions in which viral gene expression could not occur, induced high levels of RANTES expression. Replicative HCMV infection, however, induced cells in parallel cultures to express significantly lower levels of RANTES. Expression of the chemokines interleukin 8 and MCP-1 by endothelial cells was found to be unaffected by replicative HCMV infection and thus may not play an important role during early HCMV infection of the endothelium. HCMV may regulate RANTES expression from endothelial cells as a mechanism to evade the local immune response to infection.

* Corresponding author. Mailing address: Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson St., Denver, CO 80206. Phone: (303) 398-1420. Fax: (303) 270-2319. E-mail: billstroms{at}njc.org.

Journal of Virology, April 2001, p. 3383-3390, Vol. 75, No. 7
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.7.3383-3390.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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