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Journal of Virology, March 2001, p. 3038-3042, Vol. 75, No. 6
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.6.3038-3042.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Membrane-Anchored Peptide Inhibits Human Immunodeficiency Virus Entry

Markus Hildinger,1 Matthias T. Dittmar,1 Patricia Schult-Dietrich,2 Boris Fehse,3 Barbara S. Schnierle,2 Sonja Thaler,2 Gabriela Stiegler,4 Reinhold Welker,1 and Dorothee von Laer1,*

Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie an der Universität Hamburg,1 Zentrum für Knochenmarktransplantation, Universitätskrankenhaus Eppendorf,3 D-20251 Hamburg, and Georg-Speyer-Haus, 60596 Frankfurt,2 Germany, and Institute of Applied Microbiology, A-1190 Vienna, Austria4

Received 27 April 2000/Accepted 1 December 2000

Peptides derived from the heptad repeats of human immunodeficiency virus (HIV) gp41 envelope glycoprotein, such as T20, can efficiently inhibit HIV type 1 (HIV-1) entry. In this study, replication of HIV-1 was inhibited more than 100-fold in a T-helper cell line transduced with a retrovirus vector expressing membrane-anchored T20 on the cell surface. Inhibition was independent of coreceptor usage.

* Corresponding author. Mailing address: Georg-Speyer-Haus, Paul-Ehrlich-Strasse 42-44, 60596 Frankfurt, Germany. Phone: 49 69 6339 5232. Fax: 49 69 6339 5297. E-mail: laer{at}em.uni-frankfurt.de.

Journal of Virology, March 2001, p. 3038-3042, Vol. 75, No. 6
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.6.3038-3042.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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