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Journal of Virology, March 2001, p. 2468-2471, Vol. 75, No. 5
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.5.2468-2471.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Molecular and Functional Dissection of the H-2Db-Restricted Subdominant Cytotoxic T-Cell Response to Lymphocytic Choriomeningitis Virus

Denis Hudrisier,dagger Joëlle Riond, and Jean Edouard Gairin*

Laboratoire d'ImmunoPharmacologie Structurale, Institut de Pharmacologie et de Biologie Structurale, CNRS, 31400 Toulouse, France

Received 29 August 2000/Accepted 30 November 2000

Infection of H-2b mice with lymphocytic choriomeningitis virus (LCMV) generates an H-2Db-restricted cytotoxic T-lymphocyte (CTL) response whose subdominant component is directed against the GP92-101 (CSANNSHHYI) epitope. The aim of this study was to identify the functional parameters accounting for this subdominance. We found that the two naturally occurring (genetically encoded and posttranslationally modified) forms of LCMV GP92-101 were immunogenic, did not act as T-cell antagonists, and bound efficiently to but were unable to form stable complexes with H-2Db, a crucial factor for immunodominance. Thus, the H-2Db-restricted subdominant CTL response to LCMV resulted not from altered T-cell activation but from impaired major histocompatibility complex presentation properties.

* Corresponding author. Mailing address: Laboratoire d'ImmunoPharmacologie Structurale, Institut de Pharmacologie et de Biologie Structurale, CNRS, 205 route de Narbonne, 31400 Toulouse, France. Phone: 33-561-175-530. Fax: 33-561-175-532. E-mail: gairin{at}ipbs.fr.

dagger Present address: INSERM U395, CHU Purpan, 31059 Toulouse Cedex, France.

Journal of Virology, March 2001, p. 2468-2471, Vol. 75, No. 5
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.5.2468-2471.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

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  • Hudrisier, D., Riond, J., Mazarguil, H., Gairin, J. E. (2001). Pleiotropic Effects of Post-translational Modifications on the Fate of Viral Glycopeptides as Cytotoxic T Cell Epitopes. J. Biol. Chem. 276: 38255-38260 [Abstract] [Full Text]  


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