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Journal of Virology, December 2001, p. 11868-11873, Vol. 75, No. 23
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.23.11868-11873.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Recombinant Newcastle Disease Virus as a Vaccine Vector

Takaaki Nakaya,1 Jerome Cros,1 Man-Seong Park,1 Yurie Nakaya,1 Hongyong Zheng,1 Ana Sagrera,2 Enrique Villar,2 Adolfo García-Sastre,1,* and Peter Palese1,*

Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029,1 and Department of Biochemistry and Molecular Biology, University of Salamanca, Salamanca, Spain2

Received 4 May 2001/Accepted 4 September 2001

A complete cDNA clone of the Newcastle disease virus (NDV) vaccine strain Hitchner B1 was constructed, and infectious recombinant virus expressing an influenza virus hemagglutinin was generated by reverse genetics. The rescued virus induces a strong humoral antibody response against influenza virus and provides complete protection against a lethal dose of influenza virus challenge in mice, demonstrating the potential of recombinant NDV as a vaccine vector.

* Corresponding author. Mailing address: Department of Microbiology, Mount Sinai School of Medicine, One Gustave Levy Pl., New York, NY 10029. Phone for Peter Palese: (212) 241-7318. Fax: (212) 722-3634. E-mail: peter.palese{at}mssm.edu. Phone for Adolfo García-Sastre: (212) 241-7769. Fax: (212) 534-1684. E-mail: adolfo.garcia-sastre{at}mssm.edu.

Journal of Virology, December 2001, p. 11868-11873, Vol. 75, No. 23
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.23.11868-11873.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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