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Journal of Virology, November 2001, p. 11249-11252, Vol. 75, No. 22
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.22.11249-11252.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Sequences Adjacent to oriP Improve the Persistence of Epstein-Barr Virus-Based Episomes in B Cells

Robert E. White,dagger Richard Wade-Martins,Dagger and Michael R. James*

Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, Oxford OX3 7BN, United Kingdom

Received 21 May 2001/Accepted 15 August 2001

Epstein-Barr virus (EBV) oriP and the EBV nuclear antigen 1 (EBNA-1) protein allow persistence of EBV-based episomes. A nuclear matrix attachment region (MAR) spans oriP and the adjacent region of the EBV genome containing the EBV-expressed RNAs. Here, we show that episomes with the MAR are retained significantly more efficiently in EBV-positive B cells than episomes containing oriP alone.

* Corresponding author. Present address: Queensland Institute of Medical Research, 300 Herston Rd., Q 4006 Brisbane, Australia. Phone: 61-7-3362-0218. Fax: 61-7-3362-0101. E-mail: michaelJ{at}qimr.edu.au.

dagger Present address: St. James's University Hospital, Leeds LS9 7TF, United Kingdom.

Dagger Present address: Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129.

Journal of Virology, November 2001, p. 11249-11252, Vol. 75, No. 22
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.22.11249-11252.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.




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