This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sieg, S. F.
Right arrow Articles by Lederman, M. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sieg, S. F.
Right arrow Articles by Lederman, M. M.

 Previous Article  |  Next Article 

Journal of Virology, October 2001, p. 9983-9985, Vol. 75, No. 20
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.20.9983-9985.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Differential Expression of Interleukin-2 and Gamma Interferon in Human Immunodeficiency Virus Disease

Scott F. Sieg,1 Douglas A. Bazdar,1 Clifford V. Harding,2 and Michael M. Lederman1,*

Department of Medicine, Division of Infectious Diseases,1 and Department of Pathology,2 Center for AIDS Research, Case Western Reserve University, Cleveland, Ohio 44106

Received 7 March 2001/Accepted 28 June 2001

Subnormal T-cell production of interleukin-2 (IL-2) in human immunodeficiency virus (HIV) disease has been described; however, it is not clear whether failure to synthesize IL-2 represents a selective or global defect in T-cell cytokine production. We evaluated the intracellular production of gamma interferon (IFN-gamma ) and IL-2 in CD4+ cells that were stimulated with staphylococcal enterotoxin B or cytomegalovirus antigen. Strikingly, IFN-gamma and IL-2 are differentially regulated in T cells of HIV-infected patients such that the numbers of CD69+ cells or IFN-gamma -positive cells that make IL-2 are proportionally decreased in CD4+ T cells from HIV-infected patients. These findings demonstrate a selective defect in IL-2 production and suggest that enumeration of IFN-gamma -producing cells in response to T-cell receptor stimulation, while providing some estimate of antigen-reactive cell frequency, may not reflect or predict "normal" T-cell function in HIV-infected patients.

* Corresponding author. Mailing address: Division of Infectious Diseases, University Hospitals of Cleveland, AIDS Clinical Trials Unit, Foley Building, 2061 Cornell Rd., Cleveland, OH 44106. Phone: (216) 844-8175. Fax: (216) 844-5523. E-mail: lederman.michael{at}clevelandactu.org.

Journal of Virology, October 2001, p. 9983-9985, Vol. 75, No. 20
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.20.9983-9985.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Hogg, A. E., Bowick, G. C., Herzog, N. K., Cloyd, M. W., Endsley, J. J. (2009). Induction of granulysin in CD8+ T cells by IL-21 and IL-15 is suppressed by human immunodeficiency virus-1. J. Leukoc. Biol. 86: 1191-1203 [Abstract] [Full Text]  
  • Zheng, N. N., McElrath, M. J., Sow, P.-S., Hawes, S. E., Diallo-Agne, H., Stern, J. E., Li, F., Mesher, A. L., Robinson, A. D., Gottlieb, G. S., Huang, Y., Kiviat, N. B. (2007). Role of Human Immunodeficiency Virus (HIV)-Specific T-Cell Immunity in Control of Dual HIV-1 and HIV-2 Infection. J. Virol. 81: 9061-9071 [Abstract] [Full Text]  
  • Sun, Y., Permar, S. R., Buzby, A. P., Letvin, N. L. (2007). Memory CD4+ T-Lymphocyte Loss and Dysfunction during Primary Simian Immunodeficiency Virus Infection. J. Virol. 81: 8009-8015 [Abstract] [Full Text]  
  • Sun, Y., Schmitz, J. E., Acierno, P. M., Santra, S., Subbramanian, R. A., Barouch, D. H., Gorgone, D. A., Lifton, M. A., Beaudry, K. R., Manson, K., Philippon, V., Xu, L., Maecker, H. T., Mascola, J. R., Panicali, D., Nabel, G. J., Letvin, N. L. (2005). Dysfunction of Simian Immunodeficiency Virus/Simian Human Immunodeficiency Virus-Induced IL-2 Expression by Central Memory CD4+ T Lymphocytes. J. Immunol. 174: 4753-4760 [Abstract] [Full Text]  
  • Paiardini, M., Cervasi, B., Albrecht, H., Muthukumar, A., Dunham, R., Gordon, S., Radziewicz, H., Piedimonte, G., Magnani, M., Montroni, M., Kaech, S. M., Weintrob, A., Altman, J. D., Sodora, D. L., Feinberg, M. B., Silvestri, G. (2005). Loss of CD127 Expression Defines an Expansion of Effector CD8+ T Cells in HIV-Infected Individuals. J. Immunol. 174: 2900-2909 [Abstract] [Full Text]  
  • McCloskey, T. W., Haridas, V., Pontrelli, L., Pahwa, S. (2004). Response to Superantigen Stimulation in Peripheral Blood Mononuclear Cells from Children Perinatally Infected with Human Immunodeficiency Virus and Receiving Highly Active Antiretroviral Therapy. CVI 11: 957-962 [Abstract] [Full Text]  
  • Springer, K. L., Weinberg, A. (2004). Cytomegalovirus infection in the era of HAART: fewer reactivations and more immunity. J Antimicrob Chemother 54: 582-586 [Abstract] [Full Text]  
  • Sieg, S. F., Bazdar, D. A., Lederman, M. M. (2003). Impaired TCR-Mediated Induction of Ki67 by Naive CD4+ T Cells Is Only Occasionally Corrected by Exogenous IL-2 in HIV-1 Infection. J. Immunol. 171: 5208-5214 [Abstract] [Full Text]  
  • Weinberg, A., Pott, G. B. (2003). Immunity to Human Immunodeficiency Virus (HIV) in Children with Chronic HIV Infection Receiving Highly Active Antiretroviral Therapy. CVI 10: 821-825 [Abstract] [Full Text]  
  • Zhang, D., Shankar, P., Xu, Z., Harnisch, B., Chen, G., Lange, C., Lee, S. J., Valdez, H., Lederman, M. M., Lieberman, J. (2003). Most antiviral CD8 T cells during chronic viral infection do not express high levels of perforin and are not directly cytotoxic. Blood 101: 226-235 [Abstract] [Full Text]  
  • Boaz, M. J., Waters, A., Murad, S., Easterbrook, P. J., Vyakarnam, A. (2002). Presence of HIV-1 Gag-Specific IFN-{gamma}+IL-2+ and CD28+IL-2+ CD4 T Cell Responses Is Associated with Nonprogression in HIV-1 Infection. J. Immunol. 169: 6376-6385 [Abstract] [Full Text]  
  • Palmer, B. E., Boritz, E., Blyveis, N., Wilson, C. C. (2002). Discordance between Frequency of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific Gamma Interferon-Producing CD4+ T Cells and HIV-1-Specific Lymphoproliferation in HIV-1-Infected Subjects with Active Viral Replication. J. Virol. 76: 5925-5936 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»