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Journal of Virology, August 2001, p. 7732-7738, Vol. 75, No. 16
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.16.7732-7738.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Phylogenetic Analysis of Enterovirus 71 Strains Isolated during Linked Epidemics in Malaysia, Singapore, and Western Australia

Peter McMinn,1,2,* Katie Lindsay,1 David Perera,3 Hung Ming Chan,3 Kwai Peng Chan,4 and Mary Jane Cardosa3

Department of Microbiology, Princess Margaret Hospital for Children,1 and Division of Virology, TVW Telethon Institute for Child Health Research,2 Subiaco, Western Australia 6008, Australia; Institute of Health & Community Medicine, Universiti Malaysia Sarawak, 94300 Kota Samarahan, Sarawak, Malaysia3; and Department of Pathology, Singapore General Hospital, Singapore 1696084

Received 30 January 2001/Accepted 16 May 2001

Enterovirus 71 (EV71) is a frequent cause of hand, foot, and mouth disease (HFMD) epidemics associated with severe neurological sequelae in a small proportion of cases. There has been a significant increase in EV71 epidemic activity throughout the Asia-Pacific region since 1997. Recent HFMD epidemics in this region have been associated with a severe form of brainstem encephalitis associated with pulmonary edema and high case fatality rates. In this study, we show that four genetic lineages of EV71 have been prevalent in the Asia-Pacific region since 1997, including two previously undescribed genogroups (B3 and B4). Furthermore, we show that viruses belonging to genogroups B3 and B4 have circulated endemically in Southeast Asia during this period and have been the primary cause of several large HFMD or encephalitis epidemics in Malaysia, Singapore, and Western Australia.

* Corresponding author. Mailing address: Division of Virology, TVW Telethon Institute for Child Health Research, 100 Roberts Rd., Subiaco, WA 6008, Australia. Phone: 61 8 9489 7896. Fax: 61 8 9489 7700. E-mail: peterm{at}ichr.uwa.edu.au.

Journal of Virology, August 2001, p. 7732-7738, Vol. 75, No. 16
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.16.7732-7738.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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