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Journal of Virology, August 2001, p. 7723-7726, Vol. 75, No. 16
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.16.7723-7726.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Viral Load Increases in SJL/J Mice Persistently Infected by Theiler's Virus after Inactivation of the beta 2m Gene

Stéphanie Aubagnac, Michel Brahic, and Jean-François Bureau*

Unité des Virus Lents, CNRS URA 1930, Institut Pasteur, 75724 Paris Cedex 15, France

Received 20 February 2001/Accepted 16 May 2001

We show that inactivating the beta 2m gene increases the viral load of SJL/J mice persistently infected by Theiler's virus. Together with previous results, this shows that the characteristics of Tmevp1, a locus which controls the amount of viral RNA that persists in the central nervous system, are those of an H-2 class I gene.

* Corresponding author. Mailing address: Unité des Virus Lents, CNRS URA 1930, Institut Pasteur, 28, rue du Dr. Roux, 75724 Paris Cedex 15, France. Phone: (33-1) 40 61 33 25. Fax: (33-1) 40 61 31 67. E-mail: jfb{at}pasteur.fr.

Journal of Virology, August 2001, p. 7723-7726, Vol. 75, No. 16
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.16.7723-7726.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Levillayer, F., Mas, M., Levi-Acobas, F., Brahic, M., Bureau, J. F. (2007). Interleukin 22 Is a Candidate Gene for Tmevp3, a Locus Controlling Theiler's Virus-Induced Neurological Diseases. Genetics 176: 1835-1844 [Abstract] [Full Text]  
  • Trottier, M., Schlitt, B. P., Kung, A. Y., Lipton, H. L. (2004). Transition from Acute to Persistent Theiler's Virus Infection Requires Active Viral Replication That Drives Proinflammatory Cytokine Expression and Chronic Demyelinating Disease. J. Virol. 78: 12480-12488 [Abstract] [Full Text]  
  • Vigneau, S., Rohrlich, P.-S., Brahic, M., Bureau, J.-F. (2003). Tmevpg1, a Candidate Gene for the Control of Theiler's Virus Persistence, Could Be Implicated in the Regulation of Gamma Interferon. J. Virol. 77: 5632-5638 [Abstract] [Full Text]  
  • Aubagnac, S., Brahic, M., Bureau, J.-F. (2002). Bone Marrow Chimeras Reveal Non-H-2 Hematopoietic Control of Susceptibility to Theiler's Virus Persistent Infection. J. Virol. 76: 5807-5812 [Abstract] [Full Text]  


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