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Journal of Virology, July 2001, p. 6710-6713, Vol. 75, No. 14
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.14.6710-6713.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Plasmacytoid Dendritic Cells Are Highly Susceptible to Human Immunodeficiency Virus Type 1 Infection and Release Infectious Virus

Steven Patterson,1,* Aaron Rae,2 Nicola Hockey,2 Jill Gilmour,1 and Frances Gotch1

Department of Immunology, Imperial College School of Medicine, Chelsea and Westminster Hospital, London SW10 9NH,1 and Flow Cytometry Department, Imperial Cancer Research Fund, Lincolns Inn Field, London WC2 3PX,2 United Kingdom

Received 21 December 2000/Accepted 8 April 2001

Plasmacytoid dendritic cells (pcDC) and myeloid dendritic cells (myDC) are shown to express CD4 and low levels of CCR5 and CXCR4, but only myDC express DC SIGN, a C-type lectin that binds human immunodeficiency virus but does not mediate virus entry. Both DC types were more susceptible to infection with a macrophage than a lymphotropic strain of human immunodeficiency virus type 1, but pcDC were more readily infected than myDC.

* Corresponding author. Mailing address: Department of Immunology, Imperial College School of Medicine, Chelsea and Westminster Hospital, 369 Fulham Rd., London SW10 9NH, United Kingdom. Phone: 44 20 8746 5934. Fax: 44 20 8746 5997. E-mail: s.patterson{at}ic.ac.uk.

Journal of Virology, July 2001, p. 6710-6713, Vol. 75, No. 14
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.14.6710-6713.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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