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 Previous Article

Journal of Virology, July 2001, p. 6245-6248, Vol. 75, No. 13
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.13.6245-6248.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Kaposi's Sarcoma-Associated Herpesvirus Open Reading Frame 50 Represses p53-Induced Transcriptional Activity and Apoptosis

Yousang Gwack,1 Seungmin Hwang,1 Hyewon Byun,1 Chunghun Lim,1 Jin Woo Kim,2 Eui-Ju Choi,2 and Joonho Choe1,*

Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305-701,1 and National Creative Research Initiative Center for Cell Death, Graduate School of Biotechnology, Korea University, Seoul 156-701,2 Korea

Received 13 December 2000/Accepted 9 April 2001

Kaposi's sarcoma-associated herpesvirus (KSHV) open reading frame 50 (ORF50) encodes a viral transcriptional activator which stimulates the transcription of viral early and late genes of KSHV. Here we show that ORF50 represses transcriptional activity of p53 and p53-induced apoptosis through interaction with CREB binding protein (CBP). This inhibitory effect of ORF50 on the transcriptional activity of p53 was relieved by the addition of CBP. ORF50 mutants, which are defective in interaction with CBP, lost the inhibitory effects on p53. Our data provide a framework for delineating the regulatory mechanisms used by KSHV to modulate cellular transcription and the cell cycle.

* Corresponding author. Mailing address: Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea. Phone: 82-42-869-2630. Fax: 82-42-869-5630. E-mail: jchoe{at}mail.kaist.ac.kr.

Journal of Virology, July 2001, p. 6245-6248, Vol. 75, No. 13
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.13.6245-6248.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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