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Journal of Virology, July 2001, p. 6235-6241, Vol. 75, No. 13
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.13.6235-6241.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Variant Chromatin Structure of the oriP Region of Epstein-Barr Virus and Regulation of EBER1 Expression by Upstream Sequences and oriP

Barbara Wensing,1 Albert Stühler,1,dagger Peter Jenkins,1,Dagger Martine Hollyoake,1,§ Claudio Elgueta Karstegl,1 and Paul J. Farrell1,2,*

Ludwig Institute for Cancer Research1 and Virology and Cell Biology Section,2 Imperial College School of Medicine, London W2 1PG, United Kingdom

Received 19 October 2000/Accepted 3 April 2001

Most of the Epstein-Barr virus genome in latently infected cells is in a standard nucleosomal structure, but the region encompassing oriP and the Epstein-Barr virus-encoded small RNA (EBER) genes shows a distinctive pattern when digested with micrococcal nuclease. This pattern corresponds to a previously mapped nuclear matrix attachment region. Although the EBER genes are adjacent to oriP, there is only a two- to fourfold effect of oriP on EBER expression. However, sequences containing a consensus ATF site upstream of EBER1 are important for EBER1 expression.

* Corresponding author. Mailing address: Ludwig Institute for Cancer Research, Imperial College School of Medicine, Norfolk Place, London W2 1PG, United Kingdom. Phone: 44 20 7563 7703. Fax: 44 20 7724 8586. E-mail: p.farrell{at}ic.ac.uk.

dagger Present address: Department of Internal Medicine, University of Cologne, Cologne D-50931, Germany.

Dagger Present address: Department of Oncology, Cheltenham Hospital, Cheltenham, United Kingdom.

§ Present address: MRC HGMP Resource Centre, Hinxton CB10 1SB, United Kingdom.

Journal of Virology, July 2001, p. 6235-6241, Vol. 75, No. 13
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.13.6235-6241.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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