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Journal of Virology, July 2001, p. 6218-6222, Vol. 75, No. 13
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.13.6218-6222.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Heparin Inhibits Retrovirus Binding to Fibronectin as Well as Retrovirus Gene Transfer on Fibronectin Fragments

D. Carstanjen,1,* P. Dutt,2,dagger and T. Moritz3

Max Delbrück Center for Molecular Medicine, Berlin, Germany1; Herman B Wells Center for Pediatric Research, Indianapolis, Indiana2; and Department of Internal Medicine (Cancer Research), West German Cancer Center, University of Essen Medical School, Essen, Germany3

Received 10 May 2000/Accepted 30 March 2001

Fibronectin fragments have been shown to improve retrovirus gene transfer efficiency by binding retrovirus and target cells. Using a novel virus adhesion assay, we confirmed binding of type C oncoretrovirus vectors to the heparin II domain of fibronectin and demonstrated inhibition of viral binding and gene transfer by heparin.

* Corresponding author. Present address: Herman B Wells Center for Pediatric Research, Cancer Research Institute, 1044 W. Walnut St., Indianapolis, IN 46202. Phone: (317) 274-8696. Fax: (317) 274-8679. E-mail: dirk.carstanjen{at}berlin.de.

dagger Present address: Department of Physiology, Tufts University School of Medicine, Boston, Mass.

Journal of Virology, July 2001, p. 6218-6222, Vol. 75, No. 13
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.13.6218-6222.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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