This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Liang, B.
Right arrow Articles by Hou, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Liang, B.
Right arrow Articles by Hou, S.

 Previous Article  |  Next Article 

Journal of Virology, June 2001, p. 5416-5420, Vol. 75, No. 11
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.11.5416-5420.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Nasal-Associated Lymphoid Tissue Is a Site of Long-Term Virus-Specific Antibody Production following Respiratory Virus Infection of Mice

Bin Liang, Lisa Hyland, and Sam Hou*

The Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire, United Kingdom

Received 28 November 2000/Accepted 27 February 2001

Nasal immunoglobulin A provides an initial defense against inhaled respiratory pathogens. However, it is not known whether the nasal-associated lymphoid tissues (NALT) are able to mount an effective long-lasting pathogen-specific immune response, nor is it known whether functional differences exist between the organized NALT (O-NALT) and the diffuse NALT lining the nasal passages (D-NALT). Here we show that although both the O-NALT and the D-NALT are capable of producing virus-specific antibody in response to influenza virus infection, the frequency of specific antibody-forming cells in the D-NALT is much greater than the frequency observed in the O-NALT. Furthermore, we show that the D-NALT but not the O-NALT is the site of long-term virus-specific humoral immunity which lasts for the life of the animal. These results indicate that the D-NALT is not only the major effector site of the NALT but also the site of local long-term specific antibody production.

* Corresponding author. Mailing address: The Edward Jenner Institute, Compton, Newbury, Berkshire RG20 7NN, United Kingdom. Phone: 44-1635-577924. Fax: 44-1635-577901. E-mail: sam.hou{at}jenner.ac.uk.

Journal of Virology, June 2001, p. 5416-5420, Vol. 75, No. 11
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.11.5416-5420.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Joo, H. M., He, Y., Sangster, M. Y. (2008). Broad dispersion and lung localization of virus-specific memory B cells induced by influenza pneumonia. Proc. Natl. Acad. Sci. USA 105: 3485-3490 [Abstract] [Full Text]  
  • Mozdzanowska, K., Furchner, M., Zharikova, D., Feng, J., Gerhard, W. (2005). Roles of CD4+ T-Cell-Independent and -Dependent Antibody Responses in the Control of Influenza Virus Infection: Evidence for Noncognate CD4+ T-Cell Activities That Enhance the Therapeutic Activity of Antiviral Antibodies. J. Virol. 79: 5943-5951 [Abstract] [Full Text]  
  • Rharbaoui, F., Bruder, D., Vidakovic, M., Ebensen, T., Buer, J., Guzman, C. A. (2005). Characterization of a B220+ Lymphoid Cell Subpopulation with Immune Modulatory Functions in Nasal-Associated Lymphoid Tissues. J. Immunol. 174: 1317-1324 [Abstract] [Full Text]  
  • Valosky, J., Hishiki, H., Zaoutis, T. E., Coffin, S. E. (2005). Induction of Mucosal B-Cell Memory by Intranasal Immunization of Mice with Respiratory Syncytial Virus. CVI 12: 171-179 [Abstract] [Full Text]  
  • Guthrie, T., Wong, S. Y. C., Liang, B., Hyland, L., Hou, S., Hoiby, E. A., Andersen, S. R. (2004). Local and Systemic Antibody Responses in Mice Immunized Intranasally with Native and Detergent-Extracted Outer Membrane Vesicles from Neisseria meningitidis. Infect. Immun. 72: 2528-2537 [Abstract] [Full Text]  
  • Singleton, R., Etchart, N., Hou, S., Hyland, L. (2003). Inability To Evoke a Long-Lasting Protective Immune Response to Respiratory Syncytial Virus Infection in Mice Correlates with Ineffective Nasal Antibody Responses. J. Virol. 77: 11303-11311 [Abstract] [Full Text]  
  • Mozdzanowska, K., Feng, J., Gerhard, W. (2003). Virus-Neutralizing Activity Mediated by the Fab Fragment of a Hemagglutinin-Specific Antibody Is Sufficient for the Resolution of Influenza Virus Infection in SCID Mice. J. Virol. 77: 8322-8328 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»