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Journal of Virology, June 2001, p. 5370-5374, Vol. 75, No. 11
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.11.5370-5374.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Active and Selective Transcytosis of Cell-Free Human Immunodeficiency Virus through a Tight Polarized Monolayer of Human Endometrial Cells

Hakim Hocini,1,* Pierre Becquart,1 Hicham Bouhlal,1 Nicolas Chomont,1 Petronela Ancuta,1 Michel D. Kazatchkine,1,2,3 and Laurent Bélec1,2,3

INSERM U430,1 Université Pierre et Marie Curie,2 and Hôpital Européen Georges Pompidou,3 Paris, France

Received 9 August 2000/Accepted 3 March 2001

We report that both primary and laboratory-adapted infectious human immunodeficiency virus type 1 (HIV-1) isolates in a cell-free form are capable of transcytosis through a tight and polarized monolayer of human endometrial cells. Trancytosis of cell-free HIV occurs in a strain-selective fashion and appears to be dependent on interactions between HIV envelope glycoproteins and lectins on the apical membrane of the epithelial cells. These findings provide new insights into the initial events occurring during heterosexual transmission of the virus.

* Corresponding author. Mailing address: Unité INSERM U430, Hôpital Broussais, 96, rue Didot, 75 674 Paris Cedex 14, France. Phone: 33 1 43 95 95 73. Fax: 33 1 45 45 90 59. E-mail: hakim.hocini{at}brs.ap-hop-paris.fr.

Journal of Virology, June 2001, p. 5370-5374, Vol. 75, No. 11
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.11.5370-5374.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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