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Journal of Virology, May 2001, p. 4713-4720, Vol. 75, No. 10
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.10.4713-4720.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

In Vivo T-Lymphocyte Activation and Transient Reduction of Viral Replication in Macaques Infected with Simian Immunodeficiency Virus

Zheng W. Chen,1,* Yun Shen,1 Dejiang Zhou,1 Meredith Simon,2 ZhongChen Kou,1 David Lee-Parritz,2 Ling Shen,1 Prabhat Sehgal,2 and Norman L. Letvin1

Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215,1 and New England Regional Primate Research Center, Southboro, Massachusetts 017722

Received 12 December 2000/Accepted 15 February 2001

While it is well established that cellular activation can increase human immunodeficiency virus (HIV) replication in T lymphocytes, it is also clear that both activated CD8+ and CD4+ T lymphocytes mediate anti-HIV activity. To assess the relative importance of these contrary effects on HIV replication in vivo, we evaluated the consequences of Mycobacterium bovis BCG and staphylococcal enterotoxin B (SEB) inoculation in vivo in rhesus monkeys chronically infected with simian immunodeficiency virus of macaques (SIVmac). BCG inoculation induced as much as a 2.5-log reduction of plasma and intracellular SIV RNA in SIVmac-infected monkeys. This down-regulation of virus replication persisted as long as 4 weeks after BCG inoculation. Similarly, SEB injection resulted in up to a 3-log decrease in plasma and intracellular SIV RNA in SIVmac-infected macaques. Interestingly, the short-term reduction of viremia in these monkeys correlated with the peak in vivo production of SEB- and BCG-induced cytokine responses. However, no long-term clinical benefit was observed in the SIVmac-infected macaques. These studies provide in vivo evidence that potent T-cell stimulation driven by antigens other than the virus itself can, under some circumstances, mediate short-term reduction of viremia in AIDS virus-infected individuals.

* Corresponding author. Mailing address: Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Ave., RE 113, Boston, MA 02215. Phone: (617) 667-2061. Fax: (617) 667-8210. E-mail: zchen{at}caregroup.harvard.edu.

Journal of Virology, May 2001, p. 4713-4720, Vol. 75, No. 10
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.10.4713-4720.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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