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Journal of Virology, January 2001, p. 83-89, Vol. 75, No. 1
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.1.83-89.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Protective T-Cell-Based Immunity Induced in Neonatal Mice by a Single Replicative Cycle of Herpes Simplex Virus

Marco Franchini,1 Carlos Abril,1 Cornelia Schwerdel,1 Christiane Ruedl,2 Mathias Ackermann,1 and Mark Suter1,*

Institute of Virology, University of Zurich, Zurich,1 and Basel Institute for Immunology, Basel,2 Switzerland

Received 14 July 2000/Accepted 28 September 2000

Newborns are very susceptible to infections because their immune systems are not fully developed and react to antigen exposure preferentially with unresponsiveness. UV-inactivated herpes simplex virus type 1 (HSV-1) represents such an antigen and does not induce an immune response in neonates. In contrast, protective T cells were primed in newborn mice by a single replicative cycle of DISC HSV-1 given once within 24 h of birth. Each of the HSV-1-primed CD4+ or CD8+ T cells induced in wild-type or interferon-deficient mice conferred resistance to naive animals exposed to a lethal virus challenge. Inactivated HSV-1, injected at variable doses up to 104 times that of DISC HSV-1, was ineffective in inducing any detectable immune responses in neonates. Thus, the capacity of HSV-1 to replicate once, but not the number of virus particles per se, was decisive in inducing protective T-cell-associated immunity in newborn mice.

* Corresponding author. Mailing address: Institute of Virology, Winterthurerstrasse 266a, University of Zurich, 8057 Zurich, Switzerland. Phone: (1) 635-87-17. Fax: (1) 635-89-11. E-mail: msuter{at}vetvir.unizh.ch.

Journal of Virology, January 2001, p. 83-89, Vol. 75, No. 1
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.1.83-89.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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