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Journal of Virology, January 2001, p. 506-512, Vol. 75, No. 1
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.1.506-512.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

The Coronavirus Infectious Bronchitis Virus Nucleoprotein Localizes to the Nucleolus

Julian A. Hiscox,1,* Torsten Wurm,1 Louise Wilson,1 Paul Britton,2 David Cavanagh,2 and Gavin Brooks1

School of Animal and Microbial Sciences, University of Reading, Reading, Berkshire RG6 6AJ,1 and Division of Molecular Biology, Institute for Animal Health, Compton Laboratory, Compton, Newbury, Berkshire RG20 7NN,2 United Kingdom

Received 26 July 2000/Accepted 2 October 2000

The coronavirus nucleoprotein (N) has been reported to be involved in various aspects of virus replication. We examined by confocal microscopy the subcellular localization of the avian infectious bronchitis virus N protein both in the absence and in the context of an infected cell and found that N protein localizes both to the cytoplasmic and nucleolar compartments.

* Corresponding author. Mailing address: School of Animal and Microbial Sciences, University of Reading, Whiteknights, P.O. Box 228, Reading RG6 6AJ, England, United Kingdom. Phone: (0)118 931 8893. Fax: (0)118 931 0180. E-mail: j.a.hiscox{at}reading.ac.uk.

Journal of Virology, January 2001, p. 506-512, Vol. 75, No. 1
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.1.506-512.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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