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Journal of Virology, January 2001, p. 192-198, Vol. 75, No. 1
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.1.192-198.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Reciprocal Interactions between Human T-Lymphotropic Virus Type 1 and Prostaglandins: Implications for Viral Transmission

Masako Moriuchi,1 Hiroyasu Inoue,2 and Hiroyuki Moriuchi1,3,*

Division of Medical Virology, Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Medical Sciences,1 and Department of Pediatrics, Nagasaki University School of Medicine,3 Nagasaki, and Department of Pharmacology, National Cardiovascular Center Research Institute, Osaka,2 Japan

Received 15 May 2000/Accepted 22 September 2000

Human T-lymphotropic virus type 1 (HTLV-1), the etiologic agent of adult T-cell leukemia/lymphoma, is transmitted through breast milk and seminal fluid, which are rich in prostaglandins (PGs). We demonstrate that PGE2 upregulates the HTLV-1 long terminal repeat promoter through the protein kinase A pathway, induces replication of HTLV-1 in peripheral blood mononuclear cells (PBMC) derived from asymptomatic carriers, and enhances transmission of HTLV-1 to cord blood mononuclear cells (CBMC). Furthermore, HTLV-1 Tax transactivates a promoter for cyclooxygenase 2, a PG synthetase, and induces PGE2 expression in PBMC or CBMC. Thus, HTLV-1 interacts with and benefits from PGs, constituents of its own vehicle for transmission.

* Corresponding author. Mailing address: Department of Pediatrics, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan. Phone: 81-95-849-7297. Fax: 81-95-849-7301. E-mail: hiromori{at}net.nagasaki-u.ac.jp.

Journal of Virology, January 2001, p. 192-198, Vol. 75, No. 1
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.1.192-198.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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