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Journal of Virology, April 2000, p. 3905-3908, Vol. 74, No. 8
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Control of Sindbis Virus Infection by Antibody in Interferon-Deficient Mice

Andrew P. Byrnes,1 Joan E. Durbin,2 and Diane E. Griffin1,*

Department of Molecular Microbiology and Immunology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205,1 and Children's Hospital Research Foundation and Department of Pediatrics, Ohio State University, Columbus, Ohio 432052

Received 7 September 1999/Accepted 20 January 2000

Antibodies clear Sindbis virus from infected animals through an unknown mechanism. To determine whether interferon-induced pathways are required for this clearance, we examined mice which are unable to respond to alpha/beta interferon or gamma interferon. Although extremely susceptible to infection, such mice survived and completely cleared virus if antibodies against Sindbis virus were given.

* Corresponding author. Mailing address: Department of Molecular Microbiology and Immunology, Johns Hopkins University School of Hygiene and Public Health, 615 N. Wolfe St., Baltimore, MD 21205. Phone: (410) 955-3459. Fax: (410) 955-0105. E-mail: dgriffin{at}jhsph.edu.

Journal of Virology, April 2000, p. 3905-3908, Vol. 74, No. 8
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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