This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bishop, N. E.
Right arrow Articles by Anderson, D. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bishop, N. E.
Right arrow Articles by Anderson, D. A.

 Previous Article  |  Next Article 

Journal of Virology, April 2000, p. 3423-3426, Vol. 74, No. 7
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Uncoating Kinetics of Hepatitis A Virus Virions and Provirions

Naomi E. Bishop* and David A. Anderson

Hepatitis Research Unit, Macfarlane Burnet Centre for Medical Research, Fairfield, Victoria, Australia 3078

Received 6 July 1999/Accepted 22 December 1999

When the growth kinetics of immature hepatitis A virus provirions and mature virions were monitored, distinct eclipse phases were noted for both types of particles. Strikingly, uncoating of virions occurred around 4 h postinfection, while uncoating of provirions occurred predominantly between 8 and 10 h postinfection. It is proposed that the heterogenous mixture of infectious hepatitis A virus particles (virions and provirions) typically present in inocula is responsible for the normally asynchronous nature of hepatitis A virus uncoating kinetics.

* Corresponding author. Present address: School of Biological Sciences, Division of Biochemistry, 2.205 Stopford Building, Oxford Rd., Manchester M13 9PT, United Kingdom. Phone: 44 161 275 5955. Fax: 44 161 275 5082. E-mail: nebishop{at}fs2.scg.man.ac.uk.

Journal of Virology, April 2000, p. 3423-3426, Vol. 74, No. 7
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Sanchez, G., Aragones, L., Costafreda, M. I., Ribes, E., Bosch, A., Pinto, R. M. (2004). Capsid Region Involved in Hepatitis A Virus Binding to Glycophorin A of the Erythrocyte Membrane. J. Virol. 78: 9807-9813 [Abstract] [Full Text]  
  • Silberstein, E., Xing, L., van de Beek, W., Lu, J., Cheng, H., Kaplan, G. G. (2003). Alteration of Hepatitis A Virus (HAV) Particles by a Soluble Form of HAV Cellular Receptor 1 Containing the Immunoglobulin- and Mucin-Like Regions. J. Virol. 77: 8765-8774 [Abstract] [Full Text]  
  • Gauss-Muller, V., Kusov, Y. Y. (2002). Replication of a hepatitis A virus replicon detected by genetic recombination in vivo. J. Gen. Virol. 83: 2183-2192 [Abstract] [Full Text]  
  • Cohen, L., Benichou, D., Martin, A. (2002). Analysis of Deletion Mutants Indicates that the 2A Polypeptide of Hepatitis A Virus Participates in Virion Morphogenesis. J. Virol. 76: 7495-7505 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»