This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ganly, I.
Right arrow Articles by Balmain, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ganly, I.
Right arrow Articles by Balmain, A.

 Previous Article  |  Next Article 

Journal of Virology, March 2000, p. 2895-2899, Vol. 74, No. 6
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Productive Replication of Human Adenoviruses in Mouse Epidermal Cells

Ian Ganly,1 Vivien Mautner,2 and Allan Balmain1,*

CRC Department of Medical Oncology, CRC Beatson Laboratories, Glasgow G61 1BD, Scotland,1 and CRC Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham B15 2TT, England,2 United Kingdom

Received 20 July 1999/Accepted 6 December 1999

In contrast to most cells of mouse origin, cell lines derived from mouse epidermis are permissive for replication of human adenovirus type 5. The extent of epidermal cell differentiation correlated with the level of E1A expression and virus replication. Mouse epidermal cells may provide useful models for cancer therapy using replication-competent human adenoviruses.

* Corresponding author. Present address: UCSF Cancer Center, 2340 Sutter St., San Francisco, CA 94143. Phone: (415) 502 4192. Fax: (415) 502 6779. E-mail: abalmain{at}cc.ucsf.edu.

Journal of Virology, March 2000, p. 2895-2899, Vol. 74, No. 6
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Ramakrishna, E., Woller, N., Mundt, B., Knocke, S., Gurlevik, E., Saborowski, M., Malek, N., Manns, M. P., Wirth, T., Kuhnel, F., Kubicka, S. (2009). Antitumoral Immune Response by Recruitment and Expansion of Dendritic Cells in Tumors Infected with Telomerase-Dependent Oncolytic Viruses. Cancer Res. 69: 1448-1458 [Abstract] [Full Text]  
  • Jogler, C., Hoffmann, D., Theegarten, D., Grunwald, T., Uberla, K., Wildner, O. (2006). Replication properties of human adenovirus in vivo and in cultures of primary cells from different animal species.. J. Virol. 80: 3549-3558 [Abstract] [Full Text]  
  • Thomas, M. A., Spencer, J. F., La Regina, M. C., Dhar, D., Tollefson, A. E., Toth, K., Wold, W. S.M. (2006). Syrian Hamster as a Permissive Immunocompetent Animal Model for the Study of Oncolytic Adenovirus Vectors. Cancer Res. 66: 1270-1276 [Abstract] [Full Text]  
  • Preuss, M. A., Lam, J. T., Wang, M., Leath, C. A. III, Kataram, M., Mahasreshti, P. J., Alvarez, R. D., Curiel, D. T. (2004). Transcriptional Blocks Limit Adenoviral Replication in Primary Ovarian Tumor. Clin. Cancer Res. 10: 3189-3194 [Abstract] [Full Text]  
  • Booth, J. L., Coggeshall, K. M., Gordon, B. E., Metcalf, J. P. (2004). Adenovirus Type 7 Induces Interleukin-8 in a Lung Slice Model and Requires Activation of Erk. J. Virol. 78: 4156-4164 [Abstract] [Full Text]  
  • Cozzolino, M., Stagni, V., Spinardi, L., Campioni, N., Fiorentini, C., Salvati, E., Alema, S., Salvatore, A. M. (2003). p120 Catenin Is Required for Growth Factor-dependent Cell Motility and Scattering in Epithelial Cells. Mol. Biol. Cell 14: 1964-1977 [Abstract] [Full Text]  
  • Vorburger, S. A., Hunt, K. K. (2002). Adenoviral Gene Therapy. The Oncologist 7: 46-59 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»