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Journal of Virology, March 2000, p. 2885-2887, Vol. 74, No. 6
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

The Intact Retroviral Env Glycoprotein of Human Foamy Virus Is a Trimer

Thomas Wilk,1 Felix de Haas,1 Andrea Wagner,2 Twan Rutten,1 Stephen Fuller,1,3 Rolf M. Flügel,2 and Martin Löchelt2,*

Abteilung Retrovirale Genexpression, Forschungsschwerpunkt Angewandte Tumorvirologie, Deutsches Krebsforschungszentrum,2 Structural Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany,1 and Structural Biology Division, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom3

Received 29 September 1999/Accepted 8 December 1999

Electron microscopy of negatively stained human foamy virus particles provides direct evidence for the trimeric nature of intact Env surface glycoproteins. Three-dimensional image reconstruction reveals that the Env trimer is a tapering spike 14 nm in length. The spikes were often arranged in hexagonal rings which shared adjacent Env trimers.

* Corresponding author. Mailing address: Abteilung Retrovirale Genexpression, Forschungsschwerpunkt Angewandte Tumorvirologie, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 242, 69009 Heidelberg, Germany. Phone: 49-6221-424864. Fax: 49-6221-424865. E-mail: m.loechelt{at}dkfz-heidelberg.de.

Journal of Virology, March 2000, p. 2885-2887, Vol. 74, No. 6
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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