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Journal of Virology, February 2000, p. 2023-2028, Vol. 74, No. 4
0022-538X/00/$04.00+0

Resistance to Replication of Human Immunodeficiency Virus Challenge in SCID-Hu Mice Engrafted with Peripheral Blood Mononuclear Cells of Nonprogressors Is Mediated by CD8+ T Cells and Associated with a Proliferative Response to p24 Antigen

Juan Carlos Lopez Bernaldo de Quiros,1,2 W. Lesley Shupert,2 Andrew C. McNeil,2 Juan C. Gea-Banacloche,2 Mark Flanigan,2 Ann Savage,2 Lisa Martino,2 Emma E. Weiskopf,2 Hiromi Imamichi,3 Yi-Ming Zhang,3 Joseph Adelsburger,3 Randy Stevens,3 Philip M. Murphy,4 Peter A. Zimmerman,4 Claire W. Hallahan,2 Richard T. Davey Jr.,2 and Mark Connors2,*

Servicio de Medicina Interna 1, Clinica Puerta de Hierro, Universidad Autonoma de Madrid, and Servicio de Microbiologia, Hospital General Gregorio Maranon, Madrid, Spain,1 and Laboratory of Immunoregulation2 and Laboratory of Host Defense,4 National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, and SAIC/Frederick, Frederick Cancer Research and Development Center, Frederick,3 Maryland

Received 11 February 1999/Accepted 10 November 1999

High levels of resistance to challenge with human immunodeficiency virus type 1 SF162 were observed in animals engrafted with peripheral blood mononuclear cells of four long-term nonprogressors (LTNPs). Resistance was abrogated by depletion of CD8+ T cells in vivo and was observed only in LTNPs with proliferative responses to p24. In a subgroup of nonprogressors, CD8+ T cells mediated restriction of challenge viruses, and this response was associated with strong proliferative responses to p24 antigen.

* Corresponding author. Mailing address: National Institutes of Health, Building 10, Room 11B-09, 10 Center Dr., MSC 1876, Bethesda, MD 20892. Phone: (301) 496-8057. Fax: (301) 402-0070. E-mail: mconnors{at}atlas.niaid.nih.gov.

Journal of Virology, February 2000, p. 2023-2028, Vol. 74, No. 4
0022-538X/00/$04.00+0


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