This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Annunziato, P. W.
Right arrow Articles by Silverstein, S. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Annunziato, P. W.
Right arrow Articles by Silverstein, S. J.

 Previous Article  |  Next Article 

Journal of Virology, February 2000, p. 2005-2010, Vol. 74, No. 4
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Varicella-Zoster Virus Proteins in Skin Lesions: Implications for a Novel Role of ORF29p in Chickenpox

Paula W. Annunziato,1,* Octavian Lungu,2 Christos Panagiotidis,2,dagger Jing H. Zhang,1 David N. Silvers,3 Anne A. Gershon,1 and Saul J. Silverstein2

Departments of Pediatrics,1 Microbiology,2 and Dermatology and Pathology,3 College of Physicians and Surgeons, Columbia University, New York, New York

Received 10 August 1999/Accepted 8 November 1999

Skin biopsy samples from varicella-zoster virus (VZV)-infected patients examined by immunohistochemistry demonstrated VZV replication in nonepithelial cell types. ORF29p, a nonstructural nuclear protein, was found in nerves of two of six patients with chickenpox. In tissue culture, ORF29p was secreted by VZV-infected fibroblasts. Extracellular ORF29p can be taken up through endocytosis by human neurons, implying a novel role for this protein in pathogenesis.

* Corresponding author. Mailing address: Department of Pediatrics, 650 West 168th St., New York, NY 10032. Phone: (212) 305-2876. Fax: (212) 342-5218. E-mail: paa5{at}columbia.edu.

dagger Present address: Department of Pharmaceutical Sciences, Aristotle University, Thessaloniki 5006, Greece.

Journal of Virology, February 2000, p. 2005-2010, Vol. 74, No. 4
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Cohen, J. I., Krogmann, T., Pesnicak, L., Ali, M. A. (2007). Absence or Overexpression of the Varicella-Zoster Virus (VZV) ORF29 Latency-Associated Protein Impairs Late Gene Expression and Reduces VZV Latency in a Rodent Model. J. Virol. 81: 1586-1591 [Abstract] [Full Text]  
  • Zerboni, L., Ku, C.-C., Jones, C. D., Zehnder, J. L., Arvin, A. M. (2005). Varicella-zoster virus infection of human dorsal root ganglia in vivo. Proc. Natl. Acad. Sci. USA 102: 6490-6495 [Abstract] [Full Text]  
  • Sommer, M. H., Zagha, E., Serrano, O. K., Ku, C. C., Zerboni, L., Baiker, A., Santos, R., Spengler, M., Lynch, J., Grose, C., Ruyechan, W., Hay, J., Arvin, A. M. (2001). Mutational Analysis of the Repeated Open Reading Frames, ORFs 63 and 70 and ORFs 64 and 69, of Varicella-Zoster Virus. J. Virol. 75: 8224-8239 [Abstract] [Full Text]  
  • Kemble, G. W., Annunziato, P., Lungu, O., Winter, R. E., Cha, T.-A., Silverstein, S. J., Spaete, R. R. (2000). Open Reading Frame S/L of Varicella-Zoster Virus Encodes a Cytoplasmic Protein Expressed in Infected Cells. J. Virol. 74: 11311-11321 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»