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Journal of Virology, February 2000, p. 1775-1780, Vol. 74, No. 4
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Abundant Defective Viral Particles Budding from Microglia in the Course of Retroviral Spongiform Encephalopathy

Regine Hansen,1 Stefanie Czub,2 Evi Werder,2 Jens Herold,1,dagger Georg Gosztonyi,3 Hans Gelderblom,4 Simone Schimmer,1 Stefan Mazgareanu,1,Dagger Volker ter Meulen,1 and Markus Czub1,*

Institut für Virologie und Immunbiologie, Universität Würzburg, D-97078 Würzburg,1 Pathologisches Institut, Universität Würzburg, D-97080 Würzburg,2 Abt. für Neuropathologie, Universitätsklinikum Benjamin Franklin, D-12200 Berlin,3 and Robert Koch-Institut, D-13353 Berlin,4 Germany

Received 10 August 1999/Accepted 13 November 1999

A pathogenetic hallmark of retroviral neurodegeneration is the affinity of neurovirulent retroviruses for microglia cells, while degenerating neurons are excluded from retroviral infections. Microglia isolated ex vivo from rats peripherally infected with a neurovirulent retrovirus released abundant mature type C virions; however, infectivity associated with microglia was very low. In microglia, viral transcription was unaffected but envelope proteins were insufficiently cleaved into mature viral proteins and were not detected on the microglia cell surface. These microglia-specific defects in envelope protein translocation and processing not only may have prevented formation of infectious virus particles but also may have caused further cellular defects in microglia with the consequence of indirect neuronal damage. It is conceivable that similar events play a role in neuro-AIDS.

* Corresponding author. Mailing address: Institut für Virologie und Immunbiologie, Universität Würzburg, Versbacherstr. 7, D-97078 Würzburg, Germany. Phone: 49-931-201 3441. Fax: 49-931-201 3934. E-mail: czub{at}vim.uni-wuerzburg.de.

dagger Present address: Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143-0414.

Dagger Present address: Charles-River, D-88353 Kisslegg, Germany.

Journal of Virology, February 2000, p. 1775-1780, Vol. 74, No. 4
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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