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Journal of Virology, December 2000, p. 11963-11965, Vol. 74, No. 24
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Persistence and Tissue Distribution of DNA in Normal and Immunodeficient Mice Inoculated with Polyomavirus VP1 Pseudocapsid Complexes or Polyomavirus

S. Heidari,1,2,* N. Krauzewicz,3 M. Kalantari,2 A. Vlastos,1 B. E. Griffin,4 and T. Dalianis1,2

Division of Experimental Oncology, Karolinska Institute, Radiumhemmet, SE-171 76 Stockholm,1 and Division of Clinical Virology, Karolinska Institute, Huddinge University Hospital, SE-141 86 Huddinge,2 Sweden, and MRC Clinical Sciences Center, Imperial College School of Medicine, London W12 ONN,3 and Viral Oncology Unit, Division of Medicine, Imperial College School of Medicine at St. Mary's, London W2 1PG,4 United Kingdom

Received 20 July 2000/Accepted 21 September 2000

Introduction of DNA into normal and immunodeficient mice, alone or in complex with VP1 pseudocapsids, has been compared to DNA transfer by viral infection. Similar to natural infection and in contrast to plasmid alone, VP1 pseudocapsids efficiently introduced DNA, which remained for months in normal mice and possibly longer in B- and T-cell-deficient mice.

* Corresponding author. Mailing address: Cancer Center Karolinska, R8:01, Karolinska Institute, Karolinska Hospital, SE-171 76 Stockholm, Sweden. Phone: 46 8 51772764. Fax: 46 8 309195. E-mail: Shirin.Heidari{at}cck.ki.se.

Journal of Virology, December 2000, p. 11963-11965, Vol. 74, No. 24
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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