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Journal of Virology, December 2000, p. 11145-11152, Vol. 74, No. 23
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Naturally Occurring V1-env Region Variants Mediate Simian Immunodeficiency Virus SIVmac Escape from High-Titer Neutralizing Antibodies Induced by a Protective Subunit Vaccine

Harald Petry,* Katja Pekrun, Gerhard Hunsmann, Elke Jurkiewicz, and Wolfgang Lüke

Department of Virology and Immunology, German Primate Center, D-37077 Göttingen, Germany

Received 17 May 2000/Accepted 13 September 2000

Macaques which developed high-titer neutralizing antibodies (htNAb) after immunization with a virion-derived oligomeric envelope glycoprotein subunit vaccine were protected against a homologous simian immunodeficiency virus SIVmac challenge. Here we demonstrate that the htNAb could be overcome by V1-env region variants isolated ex vivo from an SIVmac-infected macaque. The results further suggest that the development of V1-env region neutralization escape mutants is also necessary for survival of the virus in infected macaques. The immunological capacity of a single variable region to induce neutralizing antibodies in vaccinated and infected macaques initiate new ideas for a successful vaccine strategy.

* Corresponding author. Mailing address: Department of Virology and Immunology, German Primate Center, Kellnerweg 4, D-37077 Göttingen, Germany. Phone: 49-551-3851-152. Fax: 49-551-3851-184. E-mail: hpetry{at}www.dpz.gwdg.de.

Journal of Virology, December 2000, p. 11145-11152, Vol. 74, No. 23
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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