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Journal of Virology, January 2000, p. 1014-1017, Vol. 74, No. 2
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Uneven Distribution of Hepatitis C Virus Quasispecies in Tissues from Subjects with End-Stage Liver Disease: Confounding Effect of Viral Adsorption and Mounting Evidence for the Presence of Low-Level Extrahepatic Replication

Tomasz Laskus,1,* Marek Radkowski,2 Lian-Fu Wang,1 Marek Nowicki,3 and Jorge Rakela1,dagger

Division of Gastroenterology and Hepatology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 152131; Institute of Infectious Diseases, Medical Academy, Warsaw, Poland2; and Maternal-Child Virology Research Laboratory, University of Southern California, Los Angeles, California 900333

Received 3 June 1999/Accepted 5 October 1999

We have found differences among the populations of hepatitis C virus sequences in serum, peripheral blood mononuclear cells (PBMCs), and various tissues in patients with chronic hepatitis C. These results are compatible with the existence of independent viral compartments in the infected host. Our results also suggest that PBMCs, and probably various tissues, can selectively adsorb viral subpopulations differing in the E2 region.

* Corresponding author. Present address: Scottsdale Mayo Clinic, SC Johnson Bldg., 13400 E. Shea Blvd., Scottsdale, AZ 85259. Phone: (480) 301-6370. Fax: (480) 301-3384. E-mail: laskus.tomasz{at}mayo.edu.

dagger Present address: Division of Transplantation Medicine, Scottsdale Mayo Clinic, Scottsdale, AZ 85259.

Journal of Virology, January 2000, p. 1014-1017, Vol. 74, No. 2
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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