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Journal of Virology, August 2000, p. 7127-7136, Vol. 74, No. 15
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Mature Dendritic Cells Infected with Herpes Simplex Virus Type 1 Exhibit Inhibited T-Cell Stimulatory Capacity

Monika Kruse,1,* Olaf Rosorius,2 Friedrich Krätzer,2 Gerhard Stelz,2 Christine Kuhnt,1 Gerold Schuler,1 Joachim Hauber,2 and Alexander Steinkasserer1

Department of Dermatology1 and Institute for Clinical and Molecular Virology,2 University of Erlangen-Nürnberg, Erlangen, Germany

Received 29 November 1999/Accepted 26 April 2000

Mature dendritic cells (DC) are the most potent antigen-presenting cells within the entire immune system. Interference with the function of these cells therefore constitutes a very powerful mechanism for viruses to escape immune responses. Several members of the Herpesviridae family have provided examples of such escape strategies, including interference with antigen presentation and production of homologous cytokines. In this study we investigated the infection of mature DC with herpes simplex virus type 1 (HSV-1) and the way in which infection alters the phenotype and function of mature DC. Interestingly, the T-cell-stimulatory capacity of these DC was strongly impaired. Furthermore, we demonstrated that HSV-1 leads to the specific degradation of CD83, a cell surface molecule which is specifically upregulated during DC maturation. These data indicate that HSV-1 has developed yet another novel mechanism to escape immune responses.

* Corresponding author. Mailing address: Department of Dermatology, University of Erlangen-Nürnberg, Hartmannstrasse 14, D-91052 Erlangen, Germany. Phone: 49-9131-853-3734. Fax: 49-9131-853-5799. E-mail: kruse{at}derma.med.uni-erlangen.de.

Journal of Virology, August 2000, p. 7127-7136, Vol. 74, No. 15
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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