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Journal of Virology, July 2000, p. 6684-6688, Vol. 74, No. 14
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Adenovirus Late Gene Expression Does Not Require a Rev-Like Nuclear RNA Export Pathway

Claudia Rabino,1 Anders Aspegren,1 Kara Corbin-Lickfett,2 and Eileen Bridge2,*

Rudbeck Laboratory, Department of Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden,1 and Department of Microbiology, Miami University, Oxford, Ohio 450562

Received 6 December 1999/Accepted 17 April 2000

Adenovirus late mRNA export is facilitated by viral early proteins of 55 and 34 kDa. The 34-kDa protein contains a leucine-rich nuclear export signal (NES) similar to that of the human immunodeficiency virus Rev protein. It was proposed that the 34-kDa protein might facilitate the export of adenovirus late mRNA through a Rev-like NES-mediated export pathway. We have tested the role of NES-mediated RNA export during adenovirus infection, and we find that it is not essential for the expression of adenovirus late genes.

* Corresponding author. Mailing address: Department of Microbiology, 32 Pearson Hall, Miami University, Oxford, OH 45056. Phone: (513) 529-7264. Fax: (513) 529-2431. E-mail: BridgeE{at}muohio.edu.

Journal of Virology, July 2000, p. 6684-6688, Vol. 74, No. 14
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

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