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Journal of Virology, June 2000, p. 5382-5384, Vol. 74, No. 11
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Evaluation of a Neonatal Rat Model for Prediction of Mumps Virus Neurovirulence in Humans

Steven A. Rubin,1,* Mikhail Pletnikov,2 Rolf Taffs,1 Phil J. Snoy,1 Darwyn Kobasa,1 Earl G. Brown,3 Kathryn E. Wright,3 and Kathryn M. Carbone1,2,4

Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 208921; Departments of Psychiatry2 and Medicine,4 The Johns Hopkins University, Baltimore, Maryland 21218; and Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada K1H 8M53

Received 22 November 1999/Accepted 8 March 2000

Neurovirulence of several mumps virus strains was assessed in a prototype rat neurovirulence test and compared to results obtained in the monkey neurovirulence test. The relative human neurovirulence of these strains was proportional to the severity of hydrocephalus in rats but not to lesion scores in the monkeys.

* Corresponding author. Mailing address: Center for Biologics Evaluation and Research, Food and Drug Administration, Building 29A, Room 1A-21, 8800 Rockville Pike, Bethesda, MD 20892. Phone: (301) 827-1974. Fax: (301) 480-5679. E-mail: rubins{at}cber.fda.gov.

Journal of Virology, June 2000, p. 5382-5384, Vol. 74, No. 11
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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