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Journal of Virology, June 2000, p. 5352-5356, Vol. 74, No. 11
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Activation of Divergent Neuronal Cell Death Pathways in Different Target Cell Populations during Neuroadapted Sindbis Virus Infection of Mice

Michael B. Havert,1 Brian Schofield,2 Diane E. Griffin,1,3 and David N. Irani1,3,*

W. Harry Feinstone Department of Molecular Microbiology and Immunology1 and Department of Environmental Health Science,2 Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205, and Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 212873

Received 6 October 1999/Accepted 10 March 2000

Infection of adult mice with neuroadapted Sindbis virus (NSV) results in a severe encephalomyelitis accompanied by prominent hindlimb paralysis. We find that the onset of paralysis parallels morphologic changes in motor neuron cell bodies in the lumbar spinal cord and in motor neuron axons in ventral nerve roots, many of which are eventually lost over time. However, unlike NSV-induced neuronal cell death found in the brain of infected animals, the loss of motor neurons does not appear to be apoptotic, as judged by morphologic and biochemical criteria. This may be explained in part by the lack of detectable caspase-3 expression in these cells.

* Corresponding author. Mailing address: Department of Molecular Microbiology and Immunology, The Johns Hopkins University School of Hygiene and Public Health, 615 N. Wolfe St., Baltimore, MD 21205-2179. Phone: (410) 955-3726. Fax: (410) 955-0105. E-mail: dirani{at}jhmi.edu.

Journal of Virology, June 2000, p. 5352-5356, Vol. 74, No. 11
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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