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Journal of Virology, May 2000, p. 4888-4890, Vol. 74, No. 10
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Cross-Reactive T-Helper Responses in Patients Infected with Different Subtypes of Human Immunodeficiency Virus Type 1

Ann-Charlotte Leandersson,1,* Gustav Gilljam,1 Malin Fredriksson,1 Jorma Hinkula,1 Annette Alaeus,2 Knut Lidman,2 Jan Albert,1 Göran Bratt,3 Eric Sandström,3 and Britta Wahren1

Karolinska Institute, Swedish Institute for Infectious Disease Control, S-171 82 Solna,1 Karolinska Hospital, M1, 171 76 Stockholm,2 and Söder Hospital, Venhälsan, S-118 83 Stockholm,3 Sweden

Received 29 September 1999/Accepted 11 February 2000

Immunization with a recombinant glycoprotein 160 envelope immunogen derived from a virus of genetic subtype B induced strong specific T-helper cell responses in asymptomatic human immunodeficiency virus (HIV) carriers infected with subtypes B to G. This indicates that the HIV-specific T-helper immunity, which is the basis for development of antibodies and cytotoxic T lymphocytes, can be improved by both homologous and heterologous antigens. It also suggests that a particular immunogen can be effective against many different HIV strains.

* Corresponding author. Mailing address: Swedish Institute for Infectious Disease Control, Karolinska Institute, Department of Virology, S-171 82 Solna, Sweden. Phone: 46-8-735 1083. Fax: 46-8-735 1080. E-mail: Ann-Charlotte.Leandersson{at}smi.ki.se.

Journal of Virology, May 2000, p. 4888-4890, Vol. 74, No. 10
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Ansari, A. F., Etzel, J. V. (2000). Immune-Based Therapies for the Management of HIV Infection: Highly Active Antiretroviral Therapy and Beyond. Journal of Pharmacy Practice 13: 515-532 [Abstract]  


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