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Journal of Virology, January 2000, p. 556-559, Vol. 74, No. 1
0022-538X/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Measles Virus Induces Functional TRAIL Production by Human Dendritic Cells

Pierre-Olivier Vidalain,* Olga Azocar, Barbara Lamouille, Anne Astier, Chantal Rabourdin-Combe, and Christine Servet-Delprat

Laboratoire d'Immunobiologie Fondamentale et Clinique, INSERM U503, ENS de Lyon, 69364 Lyon Cedex 07, France

Received 17 May 1999/Accepted 24 September 1999

Measles virus infection induces a profound immunosuppression that can lead to serious secondary infections. Here we demonstrate that measles virus induces tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mRNA and protein expression in human monocyte-derived dendritic cells. Moreover, measles virus-infected dendritic cells are shown to be cytotoxic via the TRAIL pathway.


* Corresponding author. Mailing address: Laboratoire d'Immunobiologie Fondamentale et Clinique, INSERM U503, ENS de Lyon, 46 Allée d'Italie, 69364 Lyon Cedex 07, France. Phone: (33) 4 72 72 80 13. Fax: (33) 4 72 72 86 69. E-mail: povidala{at}ens-lyon.fr.


Journal of Virology, January 2000, p. 556-559, Vol. 74, No. 1
0022-538X/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.



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