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Journal of Virology, September 1999, p. 7903-7906, Vol. 73, No. 9
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Inhibition of Borna Disease Virus Replication by Ribavirin

Ingo Jordan,1 Thomas Briese,1 Devron R. Averett,2 and W. Ian Lipkin1,*

Laboratory for the Study of Emerging Diseases, Department of Neurology, University of California, Irvine, California 92697-4292,1 and ICN Pharmaceuticals, Inc., Costa Mesa, California 926262

Received 12 February 1999/Accepted 14 June 1999

The guanosine analogue ribavirin was tested for antiviral activity in two neural cell lines, human oligodendrocytes and rat glia, against Borna disease virus (BDV) strains V and He/80. Ribavirin treatment resulted in lower levels of virus and viral transcripts within 12 h. Addition of guanosine but not adenosine resulted in a profound reduction of the ribavirin effect. Ribavirin appears to be an effective antiviral agent for treatment of BDV infection in vitro. A likely mechanism for its activity is reduction of the intracellular GTP pool, resulting in inhibition of transcription and capping of BDV mRNAs.

* Corresponding author. Mailing address: Laboratory for the Study of Emerging Diseases, Department of Neurology, University of California, Irvine, CA 92697-4292. Phone: (949) 824-6193. Fax: (949) 824-1229. E-mail: ilipkin{at}uci.edu.

Journal of Virology, September 1999, p. 7903-7906, Vol. 73, No. 9
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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