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Journal of Virology, August 1999, p. 6715-6720, Vol. 73, No. 8
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Association between Virus-Specific Cytotoxic T-Lymphocyte and Helper Responses in Human Immunodeficiency Virus Type 1 Infection

Spyros A. Kalams,1,* S. P. Buchbinder,2 E. S. Rosenberg,1 J. M. Billingsley,1 D. S. Colbert,2 N. G. Jones,1 A. K. Shea,1 A. K. Trocha,1 and B. D. Walker1

Partners AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts 02114,1 and AIDS Office, Department of Public Health, San Francisco, California 941402

Received 29 December 1998/Accepted 3 May 1999

Cellular immune responses are thought to be an important antiviral host defense, but the relationship between virus-specific T-helper and cytotoxic-T-lymphocyte (CTL) responses has not been defined. To investigate a potential link between these responses, we examined functional human immunodeficiency virus type 1 (HIV-1)-specific memory CTL precursor frequencies and p24-specific proliferative responses in a cohort of infected untreated persons with a wide range of viral loads and CD4 cell counts. Levels of p24-specific proliferative responses positively correlated with levels of Gag-specific CTL precursors and negatively correlated with levels of plasma HIV-1 RNA. These data linking the levels of HIV-specific CTL with virus-specific helper cell function during chronic viral infection provide cellular immunologic parameters to guide therapeutic and prophylactic vaccine development.

* Corresponding author. Mailing address: Massachusetts General Hospital, AIDS Research Center, 149 13th St., Rm. 5217, Charlestown, MA 02129. Phone: (617) 724-4958. Fax: (617) 726-4691. E-mail: kalams{at}helix.mgh.harvard.edu.

Journal of Virology, August 1999, p. 6715-6720, Vol. 73, No. 8
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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