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Journal of Virology, July 1999, p. 6073-6075, Vol. 73, No. 7
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

The Novel Structural Protein of Human Cytomegalovirus, pUL25, Is Localized in the Viral Tegument

N. Zini,1 M. C. Battista,2 S. Santi,1 M. Riccio,1 G. Bergamini,2 M. P. Landini,2,* and N. M. Maraldi1

Institute of Normal and Pathologic Cytomorphology, C.N.R., c/o I.O.R.,1 and Department of Clinical and Experimental Medicine, Division of Microbiology, University of Bologna, St. Orsola Hospital,2 Bologna, Italy

Received 8 February 1999/Accepted 19 March 1999

Human cytomegalovirus UL25 codes for a structural phosphoprotein of 85 kDa (C. J. Baldick and T. Shenk, J. Virol. 70:6097-6105, 1996; M. C. Battista et al., J. Virol. 73:3800-3809, 1999). In this study we analyzed the intracellular and intraviral localization of pUL25 by confocal and immunoelectron microscopy and found that pUL25 is a component of the viral tegument and the dense body matrix, acquired during the late cytoplasmic phase of virus maturation.

* Corresponding author. Mailing address: Department of Clinical and Experimental Medicine, Division of Microbiology, University of Bologna, St. Orsola General Hospital, Via Massarenti 9, 40138 Bologna, Italy. Phone: 390-51-341652. Fax: 390-51-341632. E-mail: viroland{at}med.unibo.it.

Journal of Virology, July 1999, p. 6073-6075, Vol. 73, No. 7
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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