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Journal of Virology, May 1999, p. 4443-4446, Vol. 73, No. 5
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Immunization with a Live, Attenuated Simian Immunodeficiency Virus Vaccine Leads to Restriction of Viral Diversity in Rhesus Macaques Not Protected from Pathogenic Challenge

Donald L. Sodora,1 Kristine E. Sheridan,2 Preston A. Marx,2,3 and Ruth I. Connor2,*

University of Texas Southwestern Medical Center, Dallas, Texas 752351; Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 100162; and The Tulane Regional Primate Center, Covington, Louisiana 704333

Received 28 October 1998/Accepted 25 January 1999

Rhesus macaques immunized with simian immunodeficiency virus SIVmac239Delta nef but not protected from SIVmac251 challenge were studied to determine the genetic and biological characteristics of the breakthrough viruses. Assessment of SIV genetic diversity (env V1-V2) revealed a reduction in the number of viral species in the immunized, unprotected macaques, compared to the number in nonimmunized controls. However, no evidence for selection of a specific V1-V2 genotype was observed, and biologically cloned isolates from the animals with breakthrough virus were similar with respect to replication kinetics and coreceptor use in vitro.

* Corresponding author. Mailing address: Aaron Diamond AIDS Research Center, 455 First Ave., 7th Floor, New York, NY 10016. Phone: (212) 448-5040. Fax: (212) 725-1126. E-mail: rconnor{at}adarc.org.

Journal of Virology, May 1999, p. 4443-4446, Vol. 73, No. 5
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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