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Journal of Virology, May 1999, p. 3986-3993, Vol. 73, No. 5
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Complete Sequence of Enzootic Nasal Tumor Virus, a Retrovirus Associated with Transmissible Intranasal Tumors of Sheep

Christina Cousens,1,2,* Esmeralda Minguijon,3 Robert G. Dalziel,2 Aurora Ortin,3 Mercedes Garcia,4 Jane Park,1 Lorenzo Gonzalez,4 J. Michael Sharp,1 and Marcelo de las Heras3

Moredun Research Institute1 and Royal (Dick) School of Veterinary Studies, University of Edinburgh,2 Edinburgh, United Kingdom, and Facultad de Veterinaria, Universidad de Zaragoza, Zaragoza3 and Servicio de Investigacion y Mejora Agraria, Derio,4 Spain

Received 9 September 1998/Accepted 3 February 1999

The sequence of the complete genome of ovine enzootic nasal tumor virus, an exogenous retrovirus associated exclusively with contagious intranasal tumors of sheep, was determined. The genome is 7,434 nucleotides long and exhibits a genetic organization characteristic of type B and D oncoviruses. Enzootic nasal tumor virus is closely related to the Jaagsiekte sheep retrovirus and to sheep endogenous retroviruses.

* Corresponding author. Mailing address: Moredun Research Institute, International Research Centre, Pentlands Science Park, Bush Loan, Penicuik, Midlothian EH26 0PZ, United Kingdom. Phone: (0131) 445 5111. Fax: (0131) 445 6111. E-mail: cousc{at}mri.sari.ac.uk.

Journal of Virology, May 1999, p. 3986-3993, Vol. 73, No. 5
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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