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Journal of Virology, March 1999, p. 2537-2540, Vol. 73, No. 3
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Group D Adenoviruses Infect Primary Central Nervous System Cells More Efficiently than Those from Group C

Miguel Chillon,1 Assumpció Bosch,2 Joseph Zabner,2 Lane Law,2 Donna Armentano,3 Michael J. Welsh,1,2 and Beverly L. Davidson2,*

The Department of Internal Medicine,2 Howard Hughes Medical Institute,1 University of Iowa, College of Medicine, Iowa City, Iowa, and Genzyme Corporation, Framingham, Massachusetts3

Received 21 July 1998/Accepted 10 November 1998

Group C adenovirus-mediated gene transfer to central nervous system cells is inefficient. We found that wild-type group D viruses, or recombinant adenovirus type 2 (Ad2) (group C) modified to contain Ad17 (group D) fiber, were more efficient in infecting primary cultures of neurons. Together with studies on primary vascular endothelial cells and tissue culture cell lines, our results indicate that there is not a universally applicable adenovirus serotype for use as a gene transfer vector.

* Corresponding author. Mailing address: 200 EMRB, University of Iowa, Iowa City, IA 52242. Phone: (319) 353-5511. Fax: (319) 335-7623. E-mail: beverly-davidson{at}uiowa.edu.

Journal of Virology, March 1999, p. 2537-2540, Vol. 73, No. 3
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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