This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dorrell, L.
Right arrow Articles by Rowland-Jones, S. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dorrell, L.
Right arrow Articles by Rowland-Jones, S. L.

 Previous Article  |  Next Article 

Journal of Virology, February 1999, p. 1708-1714, Vol. 73, No. 2
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Distinct Recognition of Non-Clade B Human Immunodeficiency Virus Type 1 Epitopes by Cytotoxic T Lymphocytes Generated from Donors Infected in Africa

Lucy Dorrell,1 Tao Dong,1 Graham S. Ogg,1 Simon Lister,2 Steve McAdam,1 Tim Rostron,1 Chris Conlon,3 Andrew J. McMichael,1 and Sarah L. Rowland-Jones1,*

Molecular Immunology Group, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS,1 Department of Genito-Urinary Medicine, Imperial College School of Medicine, London W2 1PG,2 and Nuffield Department of Medicine, John Radcliffe Hospital, Oxford OX3 9DU,3 United Kingdom

Received 27 July 1998/Accepted 22 October 1998

We present detailed studies of human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte (CTL) responses to clade A or C HIV type 1 in three donors infected in East Africa. We define several novel non-clade B CTL epitopes, including some restricted by HLA alleles common in Africans. Although cross-clade CTL recognition of these epitopes does occur, recognition can also be highly clade specific.

* Corresponding author. Mailing address: Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom. Phone: 44-1865-222316. Fax: 44-1865-222502. E-mail: sarah.rowland-jones{at}ndm.ox.ac.uk.

Journal of Virology, February 1999, p. 1708-1714, Vol. 73, No. 2
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Jennes, W., Camara, M., Dieye, T., Mboup, S., Kestens, L. (2008). Higher Homologous and Lower Cross-Reactive Gag-Specific T-Cell Responses in Human Immunodeficiency Virus Type 2 (HIV-2) Than in HIV-1 Infection. J. Virol. 82: 8619-8628 [Abstract] [Full Text]  
  • Peters, H. O., Mendoza, M. G., Capina, R. E., Luo, M., Mao, X., Gubbins, M., Nagelkerke, N. J. D., MacArthur, I., Sheardown, B. B., Kimani, J., Wachihi, C., Thavaneswaran, S., Plummer, F. A. (2008). An Integrative Bioinformatic Approach for Studying Escape Mutations in Human Immunodeficiency Virus Type 1 gag in the Pumwani Sex Worker Cohort. J. Virol. 82: 1980-1992 [Abstract] [Full Text]  
  • Geels, M. J., Dubey, S. A., Anderson, K., Baan, E., Bakker, M., Pollakis, G., Paxton, W. A., Shiver, J. W., Goudsmit, J. (2005). Broad Cross-Clade T-Cell Responses to Gag in Individuals Infected with Human Immunodeficiency Virus Type 1 Non-B Clades (A to G): Importance of HLA Anchor Residue Conservation. J. Virol. 79: 11247-11258 [Abstract] [Full Text]  
  • Masemola, A. M., Mashishi, T. N., Khoury, G., Bredell, H., Paximadis, M., Mathebula, T., Barkhan, D., Puren, A., Vardas, E., Colvin, M., Zijenah, L., Katzenstein, D., Musonda, R., Allen, S., Kumwenda, N., Taha, T., Gray, G., McIntyre, J., Karim, S. A., Sheppard, H. W., Gray, C. M. (2004). Novel and Promiscuous CTL Epitopes in Conserved Regions of Gag Targeted by Individuals with Early Subtype C HIV Type 1 Infection from Southern Africa. J. Immunol. 173: 4607-4617 [Abstract] [Full Text]  
  • Mwau, M., Cebere, I., Sutton, J., Chikoti, P., Winstone, N., Wee, E. G.-T., Beattie, T., Chen, Y.-H., Dorrell, L., McShane, H., Schmidt, C., Brooks, M., Patel, S., Roberts, J., Conlon, C., Rowland-Jones, S. L., Bwayo, J. J., McMichael, A. J., Hanke, T. (2004). A human immunodeficiency virus 1 (HIV-1) clade A vaccine in clinical trials: stimulation of HIV-specific T-cell responses by DNA and recombinant modified vaccinia virus Ankara (MVA) vaccines in humans. J. Gen. Virol. 85: 911-919 [Abstract] [Full Text]  
  • Hudgens, M. G, Gilbert, P. B, Self, S. G (2004). Endpoints in vaccine trials. Stat Methods Med Res 13: 89-114 [Abstract]  
  • Lopes, A. R., Jaye, A., Dorrell, L., Sabally, S., Alabi, A., Jones, N. A., Flower, D. R., De Groot, A., Newton, P., Lascar, R. M., Williams, I., Whittle, H., Bertoletti, A., Borrow, P., Maini, M. K. (2003). Greater CD8+ TCR Heterogeneity and Functional Flexibility in HIV-2 Compared to HIV-1 Infection. J. Immunol. 171: 307-316 [Abstract] [Full Text]  
  • Novitsky, V., Cao, H., Rybak, N., Gilbert, P., McLane, M. F., Gaolekwe, S., Peter, T., Thior, I., Ndung'u, T., Marlink, R., Lee, T. H., Essex, M. (2002). Magnitude and Frequency of Cytotoxic T-Lymphocyte Responses: Identification of Immunodominant Regions of Human Immunodeficiency Virus Type 1 Subtype C. J. Virol. 76: 10155-10168 [Abstract] [Full Text]  
  • Novitsky, V., Smith, U. R., Gilbert, P., McLane, M. F., Chigwedere, P., Williamson, C., Ndung'u, T., Klein, I., Chang, S. Y., Peter, T., Thior, I., Foley, B. T., Gaolekwe, S., Rybak, N., Gaseitsiwe, S., Vannberg, F., Marlink, R., Lee, T. H., Essex, M. (2002). Human Immunodeficiency Virus Type 1 Subtype C Molecular Phylogeny: Consensus Sequence for an AIDS Vaccine Design?. J. Virol. 76: 5435-5451 [Abstract] [Full Text]  
  • Currier, J. R., deSouza, M., Chanbancherd, P., Bernstein, W., Birx, D. L., Cox, J. H. (2002). Comprehensive Screening for Human Immunodeficiency Virus Type 1 Subtype-Specific CD8 Cytotoxic T Lymphocytes and Definition of Degenerate Epitopes Restricted by HLA-A0207 and -CW0304 Alleles. J. Virol. 76: 4971-4986 [Abstract] [Full Text]  
  • Ndung'u, T., Lu, Y., Renjifo, B., Touzjian, N., Kushner, N., Pena-Cruz, V., Novitsky, V. A., Lee, T.-H., Essex, M. (2001). Infectious Simian/Human Immunodeficiency Virus with Human Immunodeficiency Virus Type 1 Subtype C from an African Isolate: Rhesus Macaque Model. J. Virol. 75: 11417-11425 [Abstract] [Full Text]  
  • Novitsky, V., Rybak, N., McLane, M. F., Gilbert, P., Chigwedere, P., Klein, I., Gaolekwe, S., Chang, S. Y., Peter, T., Thior, I., Ndung'u, T., Vannberg, F., Foley, B. T., Marlink, R., Lee, T. H., Essex, M. (2001). Identification of Human Immunodeficiency Virus Type 1 Subtype C Gag-, Tat-, Rev-, and Nef-Specific Elispot-Based Cytotoxic T-Lymphocyte Responses for AIDS Vaccine Design. J. Virol. 75: 9210-9228 [Abstract] [Full Text]  
  • Korber, B., Gaschen, B., Yusim, K., Thakallapally, R., Kesmir, C., Detours, V. (2001). Evolutionary and immunological implications of contemporary HIV-1 variation. Br Med Bull 58: 19-42 [Abstract] [Full Text]  
  • Moore, J. P., Parren, P. W. H. I., Burton, D. R. (2001). Genetic Subtypes, Humoral Immunity, and Human Immunodeficiency Virus Type 1 Vaccine Development. J. Virol. 75: 5721-5729 [Full Text]  
  • Buseyne, F., Chaix, M.-L., Rouzioux, C., Blanche, S., Rivière, Y. (2001). Patient-Specific Cytotoxic T-Lymphocyte Cross-Recognition of Naturally Occurring Variants of a Human Immunodeficiency Virus Type 1 (HIV-1) p24gag Epitope by HIV-1-Infected Children. J. Virol. 75: 4941-4946 [Abstract] [Full Text]  
  • Goulder, P. J. R., Brander, C., Annamalai, K., Mngqundaniso, N., Govender, U., Tang, Y., He, S., Hartman, K. E., O'Callaghan, C. A., Ogg, G. S., Altfeld, M. A., Rosenberg, E. S., Cao, H., Kalams, S. A., Hammond, M., Bunce, M., Pelton, S. I., Burchett, S. A., McIntosh, K., Coovadia, H. M., Walker, B. D. (2000). Differential Narrow Focusing of Immunodominant Human Immunodeficiency Virus Gag-Specific Cytotoxic T-Lymphocyte Responses in Infected African and Caucasoid Adults and Children. J. Virol. 74: 5679-5690 [Abstract] [Full Text]  
  • Ogg, G. S., Kostense, S., Klein, M. R., Jurriaans, S., Hamann, D., McMichael, A. J., Miedema, F. (1999). Longitudinal Phenotypic Analysis of Human Immunodeficiency Virus Type 1-Specific Cytotoxic T Lymphocytes: Correlation with Disease Progression. J. Virol. 73: 9153-9160 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»