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Journal of Virology, February 1999, p. 1518-1527, Vol. 73, No. 2
Retrovirus Center and Virology Section,
Department of Biomedicine, University of Pisa, Pisa, Italy
Received 15 June 1998/Accepted 10 November 1998
The effects of preinfecting cats with a partially attenuated feline
immunodeficiency virus (FIV) on subsequent infection with a
fully virulent FIV belonging to a different subtype were investigated. Eight specific-pathogen-free cats were preinfected with graded doses of a long-term in vitro-cultured cell-free preparation of FIV Petaluma (FIV-P, subtype A). FIV-P established a low-grade or a silent infection in the inoculated animals. Seven months later,
the eight preinfected cats and two uninfected cats were challenged with
in vivo-grown FIV-M2 (subtype B) and periodically monitored for
immunological and virological status. FIV-P-preinfected cats were not
protected from acute infection by FIV-M2, and the sustained replication
of this virus was accompanied by a reduction of FIV-P viral loads in
the peripheral blood mononuclear cells and plasma. However, from 2 years postchallenge (p.c.) until 3 years p.c., when the experiment was
terminated, preinfected cats exhibited reduced total viral burdens, and
some also exhibited a diminished decline of circulating
CD4+ T lymphocytes relative to control cats infected with
FIV-M2 alone. Interestingly, most of the virus detected in challenged
cats at late times p.c. was of FIV-P origin, indicating that the
preinfecting, attenuated virus had become largely predominant. By the
end of follow-up, two challenged cats had no FIV-M2 detectable in the tissues examined. The possible mechanisms underlying the interplay between the two viral populations are discussed.
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
Kinetics of Replication of a Partially Attenuated Virus and of
the Challenge Virus during a Three-Year Intersubtype Feline
Immunodeficiency Virus Superinfection Experiment in Cats
*
Corresponding author. Mailing address: Dipartimento di
Biomedicina, Università di Pisa, Via San Zeno, 37, I-56127 Pisa,
Italy. Phone: 39 (050) 55 35 62. Fax: 39 (050) 55 64 55. E-mail:
bendinelli{at}biomed.unipi.it.
Journal of Virology, February 1999, p. 1518-1527, Vol. 73, No. 2
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
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