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Journal of Virology, November 1999, p. 9655-9658, Vol. 73, No. 11
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Preferential Associations of Alleles of Three Distinct Genes Argue for the Existence of Two Prototype Variants of Human Herpesvirus 7

Michael Franti, Jean-Thierry Aubin, Agnes Gautheret-Dejean, Isabelle Malet, Annie Cahour, Jean-Marie Huraux, and Henri Agut*

Laboratoire de Virologie, C.E.R.V.I., UPRES EA 2387, Hôpital Pitié-Salpétrière, 75651 Paris Cedex 13, France

Received 2 June 1999/Accepted 9 August 1999

We had previously described six distinct alleles of the glycoprotein B (gB) gene of human herpesvirus 7 (HHV-7). The genetic changes corresponding to these alleles did not affect gB gene transcription or translation in in vitro assays. The study of distinct HHV-7-positive human samples showed preferential associations of some gB alleles with some alleles of two other genes, distantly located on the HHV-7 genome, coding for the phosphoprotein p100 (p100) and the major capsid protein (MCP). Two allele combinations, corresponding to 44 and 31% of the samples studied, respectively, were interpreted as the genetic signatures of two major prototype HHV-7 variants.

* Corresponding author. Mailing address: Laboratoire de Virologie, C.E.R.V.I., UPRES EA 2387, Hôpital Pitié-Salpétrière, 83 bd de l'Hôpital, 75651 Paris Cedex 13, France. Phone: 33.1.42.17.74.01. Fax: 33.1.42.17.74.11. E-mail: henri.agut{at}psl.ap-hop-paris.fr.

Journal of Virology, November 1999, p. 9655-9658, Vol. 73, No. 11
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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Copyright © 1999 by the American Society for Microbiology. All rights reserved.