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Journal of Virology, November 1999, p. 9638-9641, Vol. 73, No. 11
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
Minimal Incidence of Serum Antibodies Reactive with
Intact Primary Isolate Virions in Human Immunodeficiency Virus Type
1-Infected Individuals
Lisa A.
Cavacini,1,*
J. Elaine
Peterson,1
Erica
Nappi,1
Mark
Duval,1
Robert
Goldstein,2
Kenneth
Mayer,2,3 and
Marshall R.
Posner1
Department of Medicine, Beth Israel Deaconess
Medical Center and Harvard Medical School,1 and
Fenway Community Health Center,2 Boston,
Massachusetts, and Department of Medicine and Division of
Infectious Diseases, Brown University School of Medicine, Pawtucket
Memorial Hospital, Pawtucket, Rhode Island3
Received 14 September 1998/Accepted 9 July 1999
Immunoglobulin G reactive with primary isolate virions was detected
in 36% of serum samples from individuals infected with human
immunodeficiency virus type 1. Of these individuals, serum samples from
only 7% captured significant quantities of virus. Virion-specific
antibody correlated with CD4 counts and, of more significance, primary
isolate neutralization. Further dissection of this response should lead
to the identification of antibodies and antigenic epitopes for vaccine purposes.
*
Corresponding author. Mailing address: Beth Israel
Deaconess Medical Center, One Deaconess Rd., BL 556, P.O. Box 15709, Boston, MA 02215. Phone: (617) 632-1161. Fax: (617) 632-0181. E-mail: lcavacin{at}caregroup.harvard.edu.
Journal of Virology, November 1999, p. 9638-9641, Vol. 73, No. 11
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
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