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Journal of Virology, November 1999, p. 9638-9641, Vol. 73, No. 11
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Minimal Incidence of Serum Antibodies Reactive with Intact Primary Isolate Virions in Human Immunodeficiency Virus Type 1-Infected Individuals

Lisa A. Cavacini,1,* J. Elaine Peterson,1 Erica Nappi,1 Mark Duval,1 Robert Goldstein,2 Kenneth Mayer,2,3 and Marshall R. Posner1

Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School,1 and Fenway Community Health Center,2 Boston, Massachusetts, and Department of Medicine and Division of Infectious Diseases, Brown University School of Medicine, Pawtucket Memorial Hospital, Pawtucket, Rhode Island3

Received 14 September 1998/Accepted 9 July 1999

Immunoglobulin G reactive with primary isolate virions was detected in 36% of serum samples from individuals infected with human immunodeficiency virus type 1. Of these individuals, serum samples from only 7% captured significant quantities of virus. Virion-specific antibody correlated with CD4 counts and, of more significance, primary isolate neutralization. Further dissection of this response should lead to the identification of antibodies and antigenic epitopes for vaccine purposes.

* Corresponding author. Mailing address: Beth Israel Deaconess Medical Center, One Deaconess Rd., BL 556, P.O. Box 15709, Boston, MA 02215. Phone: (617) 632-1161. Fax: (617) 632-0181. E-mail: lcavacin{at}caregroup.harvard.edu.

Journal of Virology, November 1999, p. 9638-9641, Vol. 73, No. 11
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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