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Journal of Virology, November 1999, p. 9604-9608, Vol. 73, No. 11
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Quasispecies of TT Virus (TTV) with Sequence Divergence in Hypervariable Regions of the Capsid Protein in Chronic TTV Infection

Tsutomu Nishizawa,1 Hiroaki Okamoto,1 Fumio Tsuda,2 Tatsuya Aikawa,3 Yoshiki Sugai,4 Keiko Konishi,5 Yoshihiro Akahane,6 Masato Ukita,1 Takeshi Tanaka,7 Yuzo Miyakawa,8 and Makoto Mayumi1,*

Immunology Division and Division of Molecular Virology, Jichi Medical School, Tochigi-Ken 329-0498,1 Department of Medical Sciences, Toshiba General Hospital, Tokyo 140-8522,2 Aikawa Internal Hospital, Ibaraki-Ken 310-0851,3 Department of Internal Medicine, Iwaki Kyoritsu General Hospital, Fukushima-Ken 973-8402,4 Department of Clinical Pathology, Kanazawa National Hospital, Ishikawa-Ken 920-0935,5 First Department of Internal Medicine, Yamanashi Medical University, Yamanashi-Ken 409-3898,6 Japanese Red Cross Saitama Blood Center, Saitama-Ken 338-0001,7 and Miyakawa Memorial Research Foundation, Tokyo 107-0062,8 Japan

Received 3 May 1999/Accepted 21 July 1999

Three hypervariable regions were identified in a central portion of open reading frame 1 of TT virus DNA, which codes for a putative capsid protein of 770 amino acids. TT virus circulates as quasispecies, with many amino acid substitutions in hypervariable regions, to evade immune surveillance of the hosts and to establish a persistent infection.

* Corresponding author. Mailing address: Minamikawachi-Machi, Tochigi-Ken 329-0498, Japan. Phone: 81-285-58-7404. Fax: 81-285-44-1557. E-mail: immundiv{at}jichi.ac.jp.

Journal of Virology, November 1999, p. 9604-9608, Vol. 73, No. 11
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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