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Journal of Virology, November 1999, p. 9584-9588, Vol. 73, No. 11
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Scrapie Pathogenesis in Subclinically Infected B-Cell-Deficient Mice

Rico Frigg,1 Michael A. Klein,1 Ivan Hegyi,1 Rolf M. Zinkernagel,2 and Adriano Aguzzi1,*

Institutes of Neuropathology1 and Experimental Immunology,2 Department of Pathology, CH-8091 Zurich, Switzerland

Received 26 April 1999/Accepted 26 July 1999

Prion infections can present without clinical manifestations. B-cell deficiency may be a model for subclinical transmissible spongiform encephalopathy, since it protects mice from disease upon intraperitoneal administration of scrapie prions; however, a proportion of B-cell-deficient mice accumulate protease-resistant prion protein in their brains. Here, we have characterized this subclinical disease. In addition, we have studied the possibility that a neurotoxic factor secreted by B cells may contribute to pathogenesis.

* Corresponding author. Mailing address: Institute of Neuropathology, University Hospital of Zurich, CH-8091 Zurich, Switzerland. Phone: 41-1-255 2107. Fax: 41-1-255 4402. E-mail: adriano{at}pathol.unizh.ch.

Journal of Virology, November 1999, p. 9584-9588, Vol. 73, No. 11
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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