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Journal of Virology, October 1999, p. 8902-8906, Vol. 73, No. 10
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Epstein-Barr Virus-Encoded RK-BARF0 Protein Expression

Norbert Kienzle,* Marion Buck, Sonia Greco, Kenia Krauer, and Tom B. Sculley

EBV Unit, The Queensland Institute of Medical Research and University of Queensland Joint Oncology Program, Brisbane, Australia

Received 21 June 1999/Accepted 29 June 1999

The cellular localization of the Epstein-Barr virus-encoded RK-BARF0 protein was analyzed by fluorescence microscopy and immunoblotting. The recombinant RK-BARF0 protein was found to be tightly bound to nuclear structures, whereas 16- to 20-kDa RK-BARF0 derivatives, generated by differential splicing of the RK-BARF0 transcript, were present throughout the cell. Moreover, a previously generated anti-RK-BARF0 rabbit serum was found to cross-react with cellular proteins, showing that the previously identified 30- to 35-kDa membrane-associated proteins do not represent RK-BARF0.

* Corresponding author. Mailing address: Queensland Institute of Medical Research, Post Office, Royal Brisbane Hospital, Brisbane, QLD 4029, Australia. Phone: 61-7-33620349. Fax: 61-7-33620106. E-mail: norbertK{at}qimr.edu.au.

Journal of Virology, October 1999, p. 8902-8906, Vol. 73, No. 10
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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