This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Oliver, P. L.
Right arrow Articles by Stoye, J. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Oliver, P. L.
Right arrow Articles by Stoye, J. P.

 Previous Article  |  Next Article 

Journal of Virology, October 1999, p. 8227-8234, Vol. 73, No. 10
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Genetic Analysis of Gv1, a Gene Controlling Transcription of Endogenous Murine Polytropic Proviruses

Peter L. Oliver and Jonathan P. Stoye*

Division of Virology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom

Received 8 March 1999/Accepted 15 June 1999

Gv1 is a genetic locus that coordinately regulates the expression of multiple murine leukemia virus-related endogenous proviral sequences. A quantitative nuclease protection assay for typing Gv1 inheritance has been developed. Use of this assay demonstrates that Gv1 controls transcription of polytropic but not of modified polytropic endogenous proviruses. A combination of genetic techniques were used to map Gv1; these analyses demonstrate that Gv1 lies approximately 37 centimorgans from the centromeric end of mouse chromosome 13.

* Corresponding author. Mailing address: Division of Virology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom. Phone: 44-208/959-3666, ext. 2140. Fax: 44-208/906-4477. E-mail: jstoye{at}nimr.mrc.ac.uk.

Journal of Virology, October 1999, p. 8227-8234, Vol. 73, No. 10
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Yoshinobu, K., Baudino, L., Santiago-Raber, M.-L., Morito, N., Dunand-Sauthier, I., Morley, B. J., Evans, L. H., Izui, S. (2009). Selective Up-Regulation of Intact, but Not Defective env RNAs of Endogenous Modified Polytropic Retrovirus by the Sgp3 Locus of Lupus-Prone Mice. J. Immunol. 182: 8094-8103 [Abstract] [Full Text]  
  • Evans, L. H., Alamgir, A. S. M., Owens, N., Weber, N., Virtaneva, K., Barbian, K., Babar, A., Malik, F., Rosenke, K. (2009). Mobilization of Endogenous Retroviruses in Mice after Infection with an Exogenous Retrovirus. J. Virol. 83: 2429-2435 [Abstract] [Full Text]  
  • Baudino, L., Yoshinobu, K., Morito, N., Kikuchi, S., Fossati-Jimack, L., Morley, B. J., Vyse, T. J., Hirose, S., Jorgensen, T. N., Tucker, R. M., Roark, C. L., Kotzin, B. L., Evans, L. H., Izui, S. (2008). Dissection of Genetic Mechanisms Governing the Expression of Serum Retroviral gp70 Implicated in Murine Lupus Nephritis. J. Immunol. 181: 2846-2854 [Abstract] [Full Text]  
  • Rankin, J., Boyle, J. J., Rose, S. J., Gabriel, L., Lewis, M., Thiruudaian, V., Rogers, N. J., Izui, S., Morley, B. J. (2007). The Bxs6 Locus of BXSB Mice Is Sufficient for High-Level Expression of gp70 and the Production of gp70 Immune Complexes. J. Immunol. 178: 4395-4401 [Abstract] [Full Text]  
  • Alamgir, A. S. M., Owens, N., Lavignon, M., Malik, F., Evans, L. H. (2005). Precise Identification of Endogenous Proviruses of NFS/N Mice Participating in Recombination with Moloney Ecotropic Murine Leukemia Virus (MuLV) To Generate Polytropic MuLVs. J. Virol. 79: 4664-4671 [Abstract] [Full Text]  
  • Kikuchi, S., Fossati-Jimack, L., Moll, T., Amano, H., Amano, E., Ida, A., Ibnou-Zekri, N., Laporte, C., Santiago-Raber, M.-L., Rozzo, S. J., Kotzin, B. L., Izui, S. (2005). Differential Role of Three Major New Zealand Black-Derived Loci Linked with Yaa-Induced Murine Lupus Nephritis. J. Immunol. 174: 1111-1117 [Abstract] [Full Text]  
  • Evans, L. H., Lavignon, M., Taylor, M., Alamgir, A. S. M. (2003). Antigenic Subclasses of Polytropic Murine Leukemia Virus (MLV) Isolates Reflect Three Distinct Groups of Endogenous Polytropic MLV-Related Sequences in NFS/N Mice. J. Virol. 77: 10327-10338 [Abstract] [Full Text]  
  • Laporte, C., Ballester, B., Mary, C., Izui, S., Reininger, L. (2003). The Sgp3 Locus on Mouse Chromosome 13 Regulates Nephritogenic gp70 Autoantigen Expression and Predisposes to Autoimmunity. J. Immunol. 171: 3872-3877 [Abstract] [Full Text]  
  • Haywood, M. E. K., Vyse, T. J., McDermott, A., Thompson, E. M., Ida, A., Walport, M. J., Izui, S., Morley, B. J. (2001). Autoantigen Glycoprotein 70 Expression Is Regulated by a Single Locus, Which Acts as a Checkpoint for Pathogenic Anti-Glycoprotein 70 Autoantibody Production and Hence for the Corresponding Development of Severe Nephritis, in Lupus-Prone BXSB Mice1. J. Immunol. 167: 1728-1733 [Abstract] [Full Text]  
  • Tucker, R. M., Vyse, T. J., Rozzo, S., Roark, C. L., Izui, S., Kotzin, B. L. (2000). Genetic Control of Glycoprotein 70 Autoantigen Production and Its Influence on Immune Complex Levels and Nephritis in Murine Lupus. J. Immunol. 165: 1665-1672 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»