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Journal of Virology, January 1999, p. 797-800, Vol. 73, No. 1
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Decay Kinetics of Human Immunodeficiency Virus-Specific Effector Cytotoxic T Lymphocytes after Combination Antiretroviral Therapy

G. S. Ogg,1 X. Jin,2 S. Bonhoeffer,2 P. Moss,1 M. A. Nowak,3 S. Monard,2 J. P. Segal,2 Y. Cao,2 S. L. Rowland-Jones,1 A. Hurley,2 M. Markowitz,2 D. D. Ho,2 A. J. McMichael,1,* and D. F. Nixon2

Institute of Molecular Medicine, Nuffield Department of Medicine, Oxford OX3 9DS1; and Institute for Advanced Study, Princeton, New Jersey 085403, United Kingdom, and Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 100162

Received 12 June 1998/Accepted 1 October 1998

Little is known of the changes in human immunodeficiency virus type 1 (HIV-1)-specific effector cytotoxic T lymphocytes (CTL) after potent antiretroviral therapy. Using HLA/peptide tetrameric complexes, we show that after starting treatment, there are early rapid fluctuations in the HIV-1-specific CTL response which last 1 to 2 weeks. These fluctuations are followed by an exponential decay (median half-life, 45 days) of HIV-1-specific CTL which continues while viremia remains undetectable. These data have implications for the immunological control of drug-resistant virus.

* Corresponding author. Mailing address: Institute of Molecular Medicine, Nuffield Department of Medicine, Oxford OX3 9DS, United Kingdom. Phone: 44 1865 222336. Fax: 44 1865 222502. E-mail: andrew.mcmichael{at}ndm.ox.ac.uk.

Journal of Virology, January 1999, p. 797-800, Vol. 73, No. 1
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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