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Journal of Virology, January 1999, p. 67-71, Vol. 73, No. 1
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Antigen-Specific Expansion of Cytotoxic T Lymphocytes in Acute Measles Virus Infection

Juthathip Mongkolsapaya,1 Assan Jaye,2 Margaret F. C. Callan,1 Albert F. Magnusen,2 Andrew J. McMichael,1,* and Hilton C. Whittle2

Molecular Immunology Group, Institute of Molecular Medicine, The John Radcliffe, Headington, Oxford OX3 9DS, United Kingdom,1 and MRC Laboratories, Banjul, Fajara, The Gambia2

Received 3 August 1998/Accepted 23 September 1998

Skewing of the T-cell receptor repertoire of CD8+ T cells has been shown in some persistent infections with viruses, such as human immunodeficiency virus, simian immunodeficiency virus, and Epstein-Barr virus. We have demonstrated that similar distortions also occur in nonpersistent measles virus infection. In addition, two of four children immunized with live, attenuated measles virus showed larger and more persistent CD8+ T-cell expansions than their naturally infected counterparts. The expanded lymphocyte populations were monoclonal or oligoclonal and lysed target cells infected with recombinant vaccinia virus expressing measles virus protein. These results demonstrate that the expansions of CD8+ T lymphocytes are antigen driven.

* Corresponding author. Mailing address: Molecular Immunology Group, Institute of Molecular Medicine, The John Radcliffe, Headington, Oxford OX3 9DS, United Kingdom. Phone: 44 1865 222336. Fax: 44 1865 222502. E-mail: andrew.mcmichael{at}ndm.ox.ac.uk.

Journal of Virology, January 1999, p. 67-71, Vol. 73, No. 1
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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